Structural changes involving tissue remodelling and fibrosis are major features of many
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …

While the coronavirus disease 19 (COVID-19) pandemic has transformed the medical and
scientific communites since it was first reported in late 2019, we are only beginning to …

Collagen-producing cells maintain the complex architecture of the lung and drive pathologic
scarring in pulmonary fibrosis. Here we perform single-cell RNA-sequencing to identify all …

Ontologically distinct populations of macrophages differentially contribute to organ fibrosis
through unknown mechanisms. We applied lineage tracing, single-cell RNA sequencing …

Fibrosis of visceral organs such as the lungs, heart, kidneys and liver remains a major cause
of morbidity and mortality and is also associated with many other disorders, including cancer …

Fibrotic diseases remain a major cause of morbidity and mortality, yet there are few effective
therapies. The underlying pathology of all fibrotic conditions is the activity of myofibroblasts …

TRF1 is an essential component of the telomeric protective complex or shelterin. We
previously showed that dysfunctional telomeres in alveolar type II (ATII) cells lead to …

To date, pulmonary fibrosis remains an unmet medical need. In this study, we evaluated the
potency of mesenchymal stromal cell (MSC) secretome components to prevent pulmonary …

Fibrosis, stiffening and scarring of an organ/tissue due to genetic abnormalities,
environmental factors, infection, and/or injury, is responsible for> 40% of all deaths in the …

Hypoxia is a sentinel feature of idiopathic pulmonary fibrosis (IPF). The IPF
microenvironment contains high lactate levels, and hypoxia enhances cellular lactate …