Harnessing the power of RADseq for ecological and evolutionary genomics

KR Andrews, JM Good, MR Miller, G Luikart… - Nature Reviews …, 2016 - nature.com
High-throughput techniques based on restriction site-associated DNA sequencing (RADseq)
are enabling the low-cost discovery and genotyping of thousands of genetic markers for any …

Molecular signatures of natural selection

R Nielsen - Annu. Rev. Genet., 2005 - annualreviews.org
There is an increasing interest in detecting genes, or genomic regions, that have been
targeted by natural selection. The interest stems from a basic desire to learn more about …

A map of recent positive selection in the human genome

BF Voight, S Kudaravalli, X Wen, JK Pritchard - PLoS biology, 2006 - journals.plos.org
The identification of signals of very recent positive selection provides information about the
adaptation of modern humans to local conditions. We report here on a genome-wide scan …

Detecting loci under selection in a hierarchically structured population

L Excoffier, T Hofer, M Foll - Heredity, 2009 - nature.com
Patterns of genetic diversity between populations are often used to detect loci under
selection in genome scans. Indeed, loci involved in local adaptations should show high F ST …

African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping

MC Campbell, SA Tishkoff - Annu. Rev. Genomics Hum. Genet., 2008 - annualreviews.org
Comparative studies of ethnically diverse human populations, particularly in Africa, are
important for reconstructing human evolutionary history and for understanding the genetic …

The evolution of molecular markers—just a matter of fashion?

C Schlötterer - Nature reviews genetics, 2004 - nature.com
In less than half a century, molecular markers have totally changed our view of nature, and
in the process they have evolved themselves. However, all of the molecular methods …

Identifying adaptive genetic divergence among populations from genome scans

MA Beaumont, DJ Balding - Molecular ecology, 2004 - Wiley Online Library
The identification of signatures of natural selection in genomic surveys has become an area
of intense research, stimulated by the increasing ease with which genetic markers can be …

Recent acceleration of human adaptive evolution

J Hawks, ET Wang, GM Cochran… - Proceedings of the …, 2007 - National Acad Sciences
Genomic surveys in humans identify a large amount of recent positive selection. Using the
3.9-million HapMap SNP dataset, we found that selection has accelerated greatly during the …

Constructing genomic maps of positive selection in humans: where do we go from here?

JM Akey - Genome research, 2009 - genome.cshlp.org
Identifying targets of positive selection in humans has, until recently, been frustratingly slow,
relying on the analysis of individual candidate genes. Genomics, however, has provided the …

The role of geography in human adaptation

G Coop, JK Pickrell, J Novembre, S Kudaravalli… - PLoS …, 2009 - journals.plos.org
Various observations argue for a role of adaptation in recent human evolution, including
results from genome-wide studies and analyses of selection signals at candidate genes …