Cellular quality control systems sense and mediate homeostatic responses to prevent the
buildup of aberrant macromolecules, which arise from errors during biosynthesis, damage …

Advances over the past 25 years have revealed much about how the structural properties of
membranes and associated proteins are linked to the thermodynamics and kinetics of …

Despite the enormous therapeutic potential of immune checkpoint blockade (ICB), it benefits
only a small subset of patients. Some chemotherapeutics can switch 'immune-cold'tumours …

Spontaneous solute and solvent permeation through membranes is of vital importance to
human life, be it gas exchange in red blood cells, metabolite excretion, drug/toxin uptake, or …

Lipid metabolism plays a major role in the regulation of the immune system. Exogenous
(dietary and microbial-derived) and endogenous (non-microbial-derived) lipids play a direct …

Sphingomyelin and cholesterol are essential lipids that are enriched in plasma membranes
of animal cells, where they interact to regulate membrane properties and many intracellular …

The identification of natural bioactive compounds aimed at promoting optimal gut health and
improving lipid metabolism is paramount in the prevention of chronic disease. In this review …

Previously we proposed that transmission of the hedgehog signal across the plasma
membrane by Smoothened is triggered by its interaction with cholesterol (Luchetti et al …

Biological membranes, primarily composed of lipids, envelop each living cell. The intricate
composition and organization of membrane lipids, including the variety of fatty acids they …

Sphingolipids are common structural components of cell membranes and are crucial for cell
functions in physiological and pathophysiological conditions. Sphingomyelin and its …