Role of gut bacterial and non-bacterial microbiota in alcohol-associated liver disease: Molecular mechanisms, biomarkers, and therapeutic prospective

N Zafari, M Velayati, M Fahim, M Maftouh, G Pourali… - Life Sciences, 2022 - Elsevier
Alcohol-associated liver disease (ALD) comprises a spectrum of liver diseases that include:
steatosis to alcohol-associated hepatitis, cirrhosis, and ultimately hepatocellular carcinoma …

Precision medicine and drug optimization in adult inflammatory bowel disease patients

S Vieujean, E Louis - Therapeutic Advances in …, 2023 - journals.sagepub.com
Inflammatory bowel diseases (IBD) encompass two main entities including ulcerative colitis
and Crohn's disease. Although having a common global pathophysiological mechanism …

Effect of prophylactic antibiotics on mortality in severe alcohol-related hepatitis: a randomized clinical trial

A Louvet, J Labreuche, T Dao, T Thévenot, F Oberti… - Jama, 2023 - jamanetwork.com
Importance The benefits of prophylactic antibiotics for hospitalized patients with severe
alcohol-related hepatitis are unclear. Objective To determine the efficacy of amoxicillin …

[HTML][HTML] Pathophysiology and management of liver cirrhosis: from portal hypertension to acute-on-chronic liver failure

RK Jagdish, A Roy, K Kumar, M Premkumar… - Frontiers in …, 2023 - frontiersin.org
Cirrhosis transcends various progressive stages from compensation to decompensation
driven by the severity of portal hypertension. The downstream effect of increasing portal …

[HTML][HTML] Narrative Review: Glucocorticoids in Alcoholic Hepatitis—Benefits, Side Effects, and Mechanisms

H Lu - Journal of Xenobiotics, 2022 - mdpi.com
Alcoholic hepatitis is a major health and economic burden worldwide. Glucocorticoids (GCs)
are the only first-line drugs recommended to treat severe alcoholic hepatitis (sAH), with …

Therapeutic targets in alcohol-associated liver disease: progress and challenges

AD Adekunle, A Adejumo… - Therapeutic Advances in …, 2023 - journals.sagepub.com
Alcohol-associated liver disease (ALD) is a complex disease with rapidly increasing
prevalence. Although there are promising therapeutic targets on the horizon, none of the …

Role of rifaximin in the management of alcohol‐associated hepatitis: A systematic review and meta‐analysis

Z Ahmed, J Badal, M Nawras… - Journal of …, 2023 - Wiley Online Library
Abstract Background and Aim Alcohol‐associated hepatitis (AAH) is an acute, inflammatory
liver disease with severe short‐term and long‐term morbidity and mortality. AAH can lead to …

Management of alcoholic hepatitis: A clinical perspective

P Kasper, S Lang, HM Steffen, M Demir - Liver International, 2023 - Wiley Online Library
Alcohol‐associated liver disease is the primary cause of liver‐related mortality worldwide
and one of the most common indications for liver transplantation. Alcoholic hepatitis …

Gut microbiome-centered therapies for alcohol-associated liver disease

T Ranjbarian, B Schnabl - Seminars in Liver Disease, 2023 - thieme-connect.com
Globally, liver disease caused by alcohol is becoming more prevalent each year. Misuse of
alcohol causes a spectrum of liver diseases, such as liver steatosis, steatohepatitis, fibrosis …

ACG Clinical Guideline: Alcohol-Associated Liver Disease

LL Jophlin, AK Singal, R Bataller… - Official journal of the …, 2024 - journals.lww.com
Alcohol-associated liver disease (ALD) is the most common cause of advanced hepatic
disease and frequent indication for liver transplantation worldwide. With harmful alcohol use …