The heterogeneity of chronic obstructive pulmonary disease (COPD) creates many
diagnostic, prognostic, treatment and management challenges, as the pathogenesis of …

The Genetic Epidemiology of COPD (COPDGene) study is a noninterventional, multicenter,
longitudinal analysis of> 10,000 subjects, including smokers with a≥ 10 pack-year history …

Background We previously described the contributions of increased total airway mucin
concentrations to the pathogenesis and diagnosis of the chronic bronchitic component of …

Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …

Background Currently, the diagnosis of chronic obstructive pulmonary disease (COPD)
requires a ratio of forced expiratory volume in 1 second (FEV1) to forced vital capacity (FVC) …

Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality
worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed …

Background Chronic obstructive pulmonary disease (COPD) is characterized by chronic
bronchitic and emphysematous components. In one biophysical model, the concentration of …

The purpose of this statement is to describe and define the phenotypic abnormalities that
can be identified on visual and quantitative evaluation of computed tomographic (CT) …

Rationale: African American individuals have worse outcomes in chronic obstructive
pulmonary disease (COPD). Objectives: To assess whether race-specific approaches for …

Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide.
We performed a genetic association study in 15,256 cases and 47,936 controls, with …