Treatment with antiretroviral therapy dramatically increases the survival of HIV-infected
individuals. However, treatment has to be continued for life because it does not lead to the …

Abstract 35 years since identification of HIV as the causative agent of AIDS, and 35 million
deaths associated with this disease, significant effort is now directed towards the …

Human immunodeficiency virus (HIV) infection is currently incurable, due to the persistence
of latently infected cells. The 'shock and kill'approach to a cure proposes to eliminate this …

The ability of HIV to establish long-lived latent infection is mainly due to transcriptional
silencing of viral genome in resting memory T lymphocytes. Here, we show that new semi …

Here, we review genomic target site selection during retroviral integration as a multistep
process in which specific biases are introduced at each level. The first asymmetries are …

The HIV-1 capsid, a conical shell encasing viral nucleoprotein complexes, is involved in
multiple post-entry processes during viral replication. Many host factors can directly bind to …

Transcriptional silencing of HIV in CD4 T cells generates a reservoir of latently infected cells
that can reseed infection after interruption of therapy. As such, these cells represent the …

Expression of the HIV-1 genome by RNA Polymerase II is regulated at multiple steps, as are
most cellular genes, including recruitment of general transcription factors and control of …

Binding of USF1/2 and TFII-I (RBF-2) at conserved sites flanking the HIV-1 LTR enhancer is
essential for reactivation from latency in T cells, with TFII-I knockdown rendering the provirus …

The final obstacle to achieving a cure to HIV/AIDS is the presence of latent HIV reservoirs
scattered throughout the body. Although antiretroviral therapy maintains plasma viral loads …