Many are frustrated with the lack of translational progress in the pain field, in which huge
gains in basic science knowledge obtained using animal models have not led to the …

The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

Acid-sensing is associated with both nociception1 and taste transduction2. Stimulation of
sensory neurons by acid is of particular interest, because acidosis accompanies many …

Traditionally, the analgesic action of nonsteroidal anti-inflammatory drugs (NSAIDs) has
been explained on the basis of their inhibition of the enzymes that synthesise …

The subject of neuroinflammation is reviewed. In response to psychological stress or certain
physical stressors, an inflammatory process may occur by release of neuropeptides …

Review Article Afferent and spinal mechanisms of joint pain Page 1 Pain, 55 (1993) 5-54 0
1993 Elsevier Science Publishers BV All rights reserved 0304-3959/93/$06.00 5 PAIN …

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We have cloned and expressed a novel proton-gated Na+ channel subunit that is specific for
sensory neurons. In COS cells, it forms a Na+ channel that responds to a drop of the …

Patients with chronic pain after whiplash injury and fibromyalgia patients display
exaggerated pain after sensory stimulation. Because evident tissue damage is usually …

Low back pain (LBP) is a common musculoskeletal symptom, which can be developed in
multiple clinical diseases. It is widely recognized that intervertebral disc (IVD) degeneration …