As we age, we experience changes in our nighttime sleep and daytime wakefulness.
Individuals afflicted with Alzheimer's disease (AD) can develop sleep problems even before …

Aging is associated with alterations in cognitive processing and brain neurophysiology.
Whereas the primary symptom of amnestic mild cognitive impairment (aMCI) is memory …

The ability to investigate therapeutic interventions in animal models of neurodegenerative
diseases depends on extensive characterization of the model (s) being used. There are …

Introduction Apathy is common in neurocognitive disorders (NCDs) such as Alzheimer's
disease and mild cognitive impairment. Although the definition of apathy is inconsistent in …

Sleep disorders are prevalent in Alzheimer's disease (AD) and a major cause of
institutionalization. Like AD pathology, sleep abnormalities can appear years before …

The 5xFAD mouse model of Alzheimer's disease (AD) rapidly develops AD‐related neuro‐
behavioral pathology. Learning and memory impairments in 5xFAD mice, however, are not …

Background Chronic neuroinflammation, aggressive amyloid beta (Aβ) deposition, neuronal
cell loss, and cognitive impairment are pathological presentations of Alzheimer's disease …

Alzheimer's disease (AD) pathology is commonly associated with cognitive decline but is
also composed of neuropsychiatric symptoms including psychological distress and …

Synapse loss and altered synaptic strength are thought to underlie cognitive impairment in
Alzheimer's disease (AD) by disrupting neural activity essential for memory. While synaptic …

Alzheimer's disease (AD) increases the risk for late-onset seizures and neuronal network
abnormalities. An elevated co-occurrence of AD and seizures has been established in the …