Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19

A Bonaventura, A Vecchié, L Dagna… - Nature Reviews …, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is a clinical syndrome caused by infection
with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with severe …

Mechanistic insights into the oxidized low‐density lipoprotein‐induced atherosclerosis

C Khatana, NK Saini, S Chakrabarti… - Oxidative medicine …, 2020 - Wiley Online Library
Dyslipidaemia has a prominent role in the onset of notorious atherosclerosis, a disease of
medium to large arteries. Atherosclerosis is the prime root of cardiovascular events …

Endothelial cell infection and endotheliitis in COVID-19

Z Varga, AJ Flammer, P Steiger, M Haberecker… - The Lancet, 2020 - thelancet.com
Cardiovascular complications are rapidly emerging as a key threat in coronavirus disease
2019 (COVID-19) in addition to respiratory disease. The mechanisms underlying the …

SARS-CoV-2 infection pathogenesis is related to oxidative stress as a response to aggression

R Cecchini, AL Cecchini - Medical hypotheses, 2020 - Elsevier
Since the WHO declared COVID-19 a pandemic, a great effort has been made to understand
this serious disease. Thousands of studies are being devoted to understanding its …

[HTML][HTML] COVID-19: the case for health-care worker screening to prevent hospital transmission

JRM Black, C Bailey, J Przewrocka, KK Dijkstra… - The Lancet, 2020 - thelancet.com
COVID-19: the case for health-care worker screening to prevent hospital transmission - The
Lancet Skip to Main Content Advertisement The Lancet Journal Submit Article Log in Register …

Coronary microvascular dysfunction

F Vancheri, G Longo, S Vancheri, M Henein - Journal of Clinical …, 2020 - mdpi.com
Many patients with chest pain undergoing coronary angiography do not show significant
obstructive coronary lesions. A substantial proportion of these patients have abnormalities in …

Autopsy findings in COVID-19-related deaths: a literature review

A Maiese, AC Manetti, R La Russa, M Di Paolo… - … Science, Medicine and …, 2021 - Springer
Although many clinical reports have been published, little is known about the pathological
post-mortem findings from people who have died of the novel coronavirus disease. The …

Endothelial dysfunction and platelet hyperactivity in type 2 diabetes mellitus: molecular insights and therapeutic strategies

R Kaur, M Kaur, J Singh - Cardiovascular diabetology, 2018 - Springer
The incidence and prevalence of diabetes mellitus is rapidly increasing worldwide at an
alarming rate. Type 2 diabetes mellitus (T2DM) is the most prevalent form of diabetes …

Cardiovascular manifestations of COVID-19 infection

A Magadum, R Kishore - Cells, 2020 - mdpi.com
SARS-CoV-2 induced the novel coronavirus disease (COVID-19) outbreak, the most
significant medical challenge in the last century. COVID-19 is associated with notable …

IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome

S Kang, T Tanaka, H Inoue, C Ono… - Proceedings of the …, 2020 - National Acad Sciences
Cytokine release syndrome (CRS) is a life-threatening complication induced by systemic
inflammatory responses to infections, including bacteria and chimeric antigen receptor T cell …