Molecular mechanisms of fluoride toxicity

O Barbier, L Arreola-Mendoza, LM Del Razo - Chemico-biological …, 2010 - Elsevier
Halfway through the twentieth century, fluoride piqued the interest of toxicologists due to its
deleterious effects at high concentrations in human populations suffering from fluorosis and …

A brief review on experimental fluorosis

E Perumal, V Paul, V Govindarajan, L Panneerselvam - Toxicology letters, 2013 - Elsevier
Fluoride (F) is a naturally occurring contaminant in the water. F is essential for normal
maintenance of teeth and bones. However, prolonged exposure to high concentration of F is …

[HTML][HTML] Fluoride exposure and kidney and liver function among adolescents in the United States: NHANES, 2013–2016

AJ Malin, C Lesseur, SA Busgang, P Curtin… - Environment …, 2019 - Elsevier
Background Hepato-and nephrotoxicity of fluoride have been demonstrated in animals, but
few studies have examined potential effects in humans. This population-based study …

[HTML][HTML] Sodium fluoride causes oxidative stress and apoptosis in the mouse liver

Y Lu, Q Luo, H Cui, H Deng, P Kuang, H Liu… - Aging (Albany …, 2017 - ncbi.nlm.nih.gov
The current study was conducted to investigate the effect of sodium fluoride (NaF) on the
oxidative stress and apoptosis as well as their relationship in the mouse liver by using …

Effect of vitamin E on monosodium glutamate induced hepatotoxicity and oxidative stress in rats

OO Onyema, EO Farombi, GO Emerole, AI Ukoha… - 2006 - nopr.niscpr.res.in
Monosodium glutamate (MSG), administered to rats (by gavage) at a dose of 0.6 mg/g body
weight for 10 days, significantly {P< 0.05) induced lipid peroxidation (LPO), decreased …

Fluoride-induced histopathology and synthesis of stress protein in liver and kidney of mice

A Chattopadhyay, S Podder, S Agarwal… - Archives of …, 2011 - Springer
Selective low (15 mg sodium fluoride (NaF)/L) and relatively high (150 mg NaF/L) doses of
in vivo fluoride (F) treatment to Swiss albino mice through drinking water elicited organ …

Fluoride-induced oxidative stress is involved in the morphological damage and dysfunction of liver in female mice

B Zhou, J Zhao, J Liu, J Zhang, J Li, H Wang - Chemosphere, 2015 - Elsevier
Fluoride (F), one of the most toxic environmental and industrial pollutants, is known to exert
hepatotoxicity. The contribution of oxidative stress to the F tolerance of liver remains largely …

[PDF][PDF] Fluoride and oxidative stress

D Chlubek, S Poland - Fluoride, 2003 - fluorideresearch.org
Biological reduction of molecular oxygen (O2) generates products collectively termed
reactive oxygen species (ROS). By accepting a single electron, O2 is transformed into the …

Effects of individual and combined exposure to sodium arsenite and sodium fluoride on tissue oxidative stress, arsenic and fluoride levels in male mice

M Mittal, SJS Flora - Chemico-biological interactions, 2006 - Elsevier
Arsenic and fluoride are potent toxicants, widely distributed through drinking water and food
and often result in adverse health effects. The present study examined the effects of sodium …

Fluoride exposure impairs glucose tolerance via decreased insulin expression and oxidative stress

EA García-Montalvo, H Reyes-Pérez, LM Del Razo - Toxicology, 2009 - Elsevier
Chronic exposure to high fluoride (F−) may lead to local tissue disturbances, known as
fluorosis. F− is an oxidising agent and a well-known reversible enzymatic inhibitor that …