Adrenal glucocorticoids are major modulators of multiple functions, including energy
metabolism, stress responses, immunity, and cognition. The endogenous secretion of …

Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …

Most aspects of energy metabolism display clear variations during day and night. This daily
rhythmicity of metabolic functions, including hormone release, is governed by a circadian …

Circadian and seasonal rhythms are a fundamental feature of all living organisms and their
organelles. Biological rhythms are responsible for daily food intake; the period of hunger …

In association with sleep–wake and fasting–feeding cycles, organisms experience dramatic
oscillations in energetic demands and nutrient supply. It is therefore not surprising that …

Osteoarthritis (OA) is the most prevalent and debilitating joint disease, and there are
currently no effective disease-modifying treatments available. Multiple risk factors for OA …

Introduction: Circadian rhythms regulate much of gastrointestinal physiology including cell
proliferation, motility, digestion, absorption, and electrolyte balance. Disruption of circadian …

The mammalian circadian clock system, which includes the master clock and peripheral
clocks, times different biological processes in reaction to external cues, such as the light …

Objectives The circadian clocks are internal timing mechanisms that drive∼ 24-hour
rhythms in a tissue-specific manner. Many aspects of the physiology of the intervertebral disc …

Clock genes respond to external stimuli and exhibit circadian rhythms. This study
investigated the expression of clock genes in the small intestine and their contribution in the …