Skeletal muscle possesses a remarkable ability to adapt to various physiologic conditions.
AMPK is a sensor of intracellular energy status that maintains energy stores by fine-tuning …

Teleost muscle first arises in early embryonic life and its development is driven by molecules
present in the egg yolk and modulated by environmental stimuli including temperature and …

Obesity has become a serious public health problem and a major risk factor for the
development of illnesses, such as insulin resistance and hypertension. Human homeostatic …

Many behaviors and physiological activities in living organisms display circadian rhythms,
allowing the organisms to anticipate and prepare for the diurnal changes in the living …

Although obesity is considered to result from an imbalance between energy uptake and
energy expenditure, the strategy of dietary changes and physical exercise has failed to …

Circadian rhythms that influence mammalian homeostasis and overall health have received
increasing interest over the past two decades. The molecular clock, which is present in …

Cellular metabolite balance and mitochondrial function are under circadian control, but the
pathways connecting the molecular clock to these functions are unclear. Peroxisome …

Increased longevity and improved health can be achieved in mammals by two feeding
regimens, caloric restriction (CR), which limits the amount of daily calorie intake, and …

Circadian clocks coordinate behavior and physiology with daily environmental cycles and
thereby optimize the timing of metabolic processes such as glucose production and insulin …

The circadian clock coordinates cellular and organismal energy metabolism [1]. The
importance of this circadian timing system is underscored by findings that defects in the …