Neurological disorders affecting the central nervous system (CNS) are still incompletely
understood. Many of these disorders lack a cure and are seeking more specific and effective …

Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting∼ 1% of
people over the age of 65. Neuropathological hallmarks of PD are prominent loss of …

Based on valuable customer feedback, Doctors Yanoff and Duker have streamlined their
best-selling reference, Ophthalmology, to zero in on just the clinical answers you need in …

We compared adeno-associated virus (AAV) serotypes for expression levels of green
fluorescent protein (GFP) in the adult rat hippocampus by biophotonic imaging. Preparations …

Insulin‐like growth factor 2 (IGF2) was recently found to play a critical role in memory
consolidation in rats and mice, and hippocampal or systemic administration of recombinant …

The invention in some aspects relates to recombinant adeno-associated viruses having
distinct tissue targeting capabilities. In some aspects, the invention relates to gene transfer …

Elimination of specific surface-exposed single tyrosine (Y) residues substantially improves
hepatic gene transfer with adeno-associated virus type 2 (AAV2) vectors. Here …

Researchers have conducted numerous pre-clinical and clinical gene transfer studies using
recombinant viral vectors derived from a wide range of pathogenic viruses such as …

Background Gene transfer to nociceptive neurons of the dorsal root ganglia (DRG) is a
promising approach to dissect mechanisms of pain in rodents and is a potential therapeutic …

Retrograde transport of viral vectors in the rodent spinal cord provides a powerful means to
administer a therapeutic transgene from the innervated musculature. With the aim of scaling …