Transcriptional regulators of claudins in epithelial tight junctions

N Khan, AR Asif - Mediators of inflammation, 2015 - Wiley Online Library
Human gastrointestinal tract is covered by a monolayer of specialized epithelial cells that
constitute a protective barrier surface to external toxic and infectious agents along with …

[HTML][HTML] Flavodoxins as Novel Therapeutic Targets against Helicobacter pylori and Other Gastric Pathogens

S Salillas, J Sancho - International Journal of Molecular Sciences, 2020 - mdpi.com
Flavodoxins are small soluble electron transfer proteins widely present in bacteria and
absent in vertebrates. Flavodoxins participate in different metabolic pathways and, in some …

Comparative proteomics reveals Cryptosporidium parvum infection disrupts cellular barriers

L Wang, Z Cui, N Li, G Liang, X Zhang, Y Wang, D Li… - Journal of …, 2023 - Elsevier
Cryptosporidium is a protozoan parasite capable of infecting humans and animals and is a
leading cause of diarrheal disease and early childhood mortality. The molecular …

The biological challenges and pharmacological opportunities of orally administered nanomedicine delivery

DM Moss, P Curley, H Kinvig, C Hoskins… - Expert Review of …, 2018 - Taylor & Francis
Introduction: Nano-scale formulations are being developed to improve the delivery of orally
administered medicines, and the interactions between nanoformulations and the …

Virulence factors impair epithelial junctions during bacterial infection

M Zheng, S Sun, J Zhou, M Liu - Journal of Clinical Laboratory …, 2021 - Wiley Online Library
Epithelial cells are typically connected through different types of cell junctions that are
localized from the apical membrane to the basal surface. In this way, epithelium cells form …

Alterations of the apical junctional complex and actin cytoskeleton and their role in colorectal cancer progression

AS Gehren, MR Rocha, WF de Souza… - Tissue …, 2015 - Taylor & Francis
Colorectal cancer represents the fourth highest mortality rate among cancer types
worldwide. An understanding of the molecular mechanisms that regulate their progression …

Intracellular delivery of oligonucleotides in Helicobacter pylori by fusogenic liposomes in the presence of gastric mucus

RS Santos, GR Dakwar, E Zagato, T Brans… - Biomaterials, 2017 - Elsevier
The rising antimicrobial resistance contributes to 25000 annual deaths in Europe. This threat
to the public health can only be tackled if novel antimicrobials are developed, combined with …

Bacillus thuringiensis targets the host intestinal epithelial junctions for successful infection of Caenorhabditis elegans

L Wan, J Lin, H Du, Y Zhang, A Bravo… - Environmental …, 2019 - Wiley Online Library
Pathogenic bacteria use different strategies to infect their hosts, including the simultaneous
production of pore forming toxins and several virulence factors that may synergize their …

[HTML][HTML] E-cadherin roles in animal biology: A perspective on thyroid hormone-influence

MF Izaguirre, VH Casco - Cell Communication and Signaling, 2016 - Springer
The establishment, remodeling and maintenance of tissular architecture during animal
development, and even across juvenile to adult life, are deeply regulated by a delicate …

[HTML][HTML] Identification of host protein ENO1 (alpha-enolase) interacting with Cryptosporidium parvum sporozoite surface protein, Cpgp40

Y Wang, N Li, G Liang, L Wang, X Zhang, Z Cui, X Li… - Parasites & …, 2024 - Springer
Background Cryptosporidium parvum is an apicomplexan zoonotic parasite causing the
diarrheal illness cryptosporidiosis in humans and animals. To invade the host intestinal …