The history of brain drug delivery is reviewed beginning with the first demonstration, in 1914,
that a drug for syphilis, salvarsan, did not enter the brain, due to the presence of a blood …

The blood–brain barrier (BBB) is a critical biological structure that prevents damage to the
brain and maintains its bathing microenvironment. However, this barrier is also the obstacle …

Magnetic Nanoparticles (MNPs) are of great interest in biomedicine, due to their wide range
of applications. During recent years, one of the most challenging goals is the development of …

Brain diseases, such as brain tumors, neurodegenerative diseases, cerebrovascular
diseases, and brain injuries, are caused by various pathophysiological changes, which pose …

Drug delivery to the brain has been one of the toughest challenges researchers have faced
to develop effective treatments for brain diseases. Owing to the blood–brain barrier (BBB) …

The blood–brain barrier (BBB) is an efficient barrier for molecules and drugs. Multicellular
3D spheroids display reproducible BBB features and functions. The spheroids used here …

Glioblastoma (GBM) as the most common primary malignant brain tumor exhibits a high
incidence and degree of malignancy as well as poor prognosis. Due to the existence of …

This review article summarizes the development of different kinds of materials that evolved
interest in all field of science particularly on new nano-materials which possess both electric …

Recently, magnetic nanoparticles (MNPs) have more and more often been used in
experimental studies on cancer treatments, which have become one of the biggest …

Artificial, de-novo manufactured materials (with controlled nano-sized characteristics) have
been progressively used by neuroscientists during the last several decades. The …