Synthesis, Antioxidant and Antiproliferative Actions of 4-(1,2,3-Triazol-1-yl)quinolin-2(1H)-ones as Multi-Target Inhibitors
EM El-Sheref, S Bräse, HN Tawfeek… - International Journal of …, 2023 - mdpi.com
The reaction of 4-azido-quinolin-2 (1 H)-ones 1a–e with the active methylene compounds
pentane-2, 4-dione (2a), 1, 3-diphenylpropane-1, 3-dione (2b), and K2CO3 was investigated …
pentane-2, 4-dione (2a), 1, 3-diphenylpropane-1, 3-dione (2b), and K2CO3 was investigated …
Design, synthesis, and modelling study of new 1, 2, 3‐triazole/chalcone hybrids with antiproliferative action as epidermal growth factor receptor inhibitors
MTE Maghraby, OIA Salem… - Chemical Biology & …, 2023 - Wiley Online Library
Abstract A novel series of 1, 2, 3‐triazole/chalcone hybrids 6a–n was designed and
synthesized using a molecular hybridization approach to develop a new cytotoxic agent …
synthesized using a molecular hybridization approach to develop a new cytotoxic agent …
Chemical Constituent Profiling of Phyllostachys heterocycla var. Pubescens with Selective Cytotoxic Polar Fraction through EGFR Inhibition in HepG2 Cells
Different extracts of the Bamboo shoot skin Phyllostachys heterocycla var. pubescens were
screened against panel of cancer cell lines and normal one. The cell viability results …
screened against panel of cancer cell lines and normal one. The cell viability results …
Synthesis and Structure Determination of Substituted Thiazole Derivatives as EGFR/BRAFV600E Dual Inhibitors Endowed with Antiproliferative Activity
2, 3, 4-trisubstituted thiazoles 3a–i, having a methyl group in position four, were synthesized
by the reaction of 1, 4-disubstituted thiosemicarbazides with chloroacetone in ethyl …
by the reaction of 1, 4-disubstituted thiosemicarbazides with chloroacetone in ethyl …
Design, synthesis, biological evaluation, and computational studies of novel tri-aryl imidazole-benzene sulfonamide hybrids as promising selective carbonic …
A novel series of tri-aryl imidazole derivatives 5a–n carrying benzene sulfonamide moiety
has been designed for their selective inhibitory against hCA IX and XII activity. Six …
has been designed for their selective inhibitory against hCA IX and XII activity. Six …
Design and Synthesis of (2-oxo-1,2-Dihydroquinolin-4-yl)-1,2,3-triazole Derivatives via Click Reaction: Potential Apoptotic Antiproliferative Agents
A mild and versatile method based on Cu-catalyzed [2+ 3] cycloaddition (Huisgen-Meldal-
Sharpless reaction) was developed to tether 3, 3'-((4-(prop-2-yn-1-yloxy) phenyl) methylene) …
Sharpless reaction) was developed to tether 3, 3'-((4-(prop-2-yn-1-yloxy) phenyl) methylene) …
[HTML][HTML] Design, synthesis, crystal structures and biological evaluation of some 1, 3-thiazolidin-4-ones as dual CDK2/EGFR potent inhibitors with potential apoptotic …
A series of novel thiazolidine-4-one derivatives was synthesized by reacting 1, 4-
disubstituted hydrazine carbothioamides with diethyl azodicarboxylate. The structures were …
disubstituted hydrazine carbothioamides with diethyl azodicarboxylate. The structures were …
Synthesis of novel amidines via one-pot three component reactions: Selective topoisomerase I inhibitors with antiproliferative properties
EM El-Sheref, HN Tawfeek, AA Hassan, S Bräse… - Frontiers in …, 2022 - frontiersin.org
Novel series of amidines were synthesized via the interaction between alicyclic amines,
cyclic ketones, and a highly electrophilic 4-azidoquinolin-2 (1 H)-ones without any catalyst …
cyclic ketones, and a highly electrophilic 4-azidoquinolin-2 (1 H)-ones without any catalyst …
Recent trends in rationally designed molecules as kinase inhibitors
Protein kinases modulate the structure and function of proteins by adding phosphate groups
to threonine, tyrosine, and serine residues. The phosphorylation process mediated by the …
to threonine, tyrosine, and serine residues. The phosphorylation process mediated by the …
Recent Updates on Indole Derivatives as Kinase Inhibitors in the Treatment of Cancer
V Asati, R Bhupal, S Bhattacharya… - Anti-Cancer Agents …, 2023 - ingentaconnect.com
Cancer is becoming a global threat as its treatment accounts for many challenges. Hence,
newer inventions prioritize the requirement of developing novel anticancer agents. In this …
newer inventions prioritize the requirement of developing novel anticancer agents. In this …