Recent update on basic mechanisms of spinal cord injury
Spinal cord injury (SCI) is a life-shattering neurological condition that affects between
250,000 and 500,000 individuals each year with an estimated two to three million people …
250,000 and 500,000 individuals each year with an estimated two to three million people …
Axon physiology
D Debanne, E Campanac, A Bialowas… - Physiological …, 2011 - journals.physiology.org
Axons are generally considered as reliable transmission cables in which stable propagation
occurs once an action potential is generated. Axon dysfunction occupies a central position in …
occurs once an action potential is generated. Axon dysfunction occupies a central position in …
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
Here we conducted a large-scale genetic association analysis of educational attainment in a
sample of approximately 1.1 million individuals and identify 1,271 independent genome …
sample of approximately 1.1 million individuals and identify 1,271 independent genome …
[HTML][HTML] Transcriptional architecture of synaptic communication delineates GABAergic neuron identity
Understanding the organizational logic of neural circuits requires deciphering the biological
basis of neuronal diversity and identity, but there is no consensus on how neuron types …
basis of neuronal diversity and identity, but there is no consensus on how neuron types …
[HTML][HTML] Deep sequencing of somatosensory neurons reveals molecular determinants of intrinsic physiological properties
Dorsal root ganglion (DRG) sensory neuron subtypes defined by their in vivo properties
display distinct intrinsic electrical properties. We used bulk RNA sequencing of genetically …
display distinct intrinsic electrical properties. We used bulk RNA sequencing of genetically …
Neuronal activity-induced, equilibrative nucleoside transporter-dependent, somatodendritic adenosine release revealed by a GRAB sensor
The purinergic signaling molecule adenosine (Ado) modulates many physiological and
pathological functions in the brain. However, the exact source of extracellular Ado remains …
pathological functions in the brain. However, the exact source of extracellular Ado remains …
Genotype-phenotype correlations in SCN8A-related disorders reveal prognostic and therapeutic implications
KM Johannesen, Y Liu, M Koko, CE Gjerulfsen… - Brain, 2022 - academic.oup.com
We report detailed functional analyses and genotype-phenotype correlations in 392
individuals carrying disease-causing variants in SCN8A, encoding the voltage-gated Na+ …
individuals carrying disease-causing variants in SCN8A, encoding the voltage-gated Na+ …
[HTML][HTML] FMRP regulates neurotransmitter release and synaptic information transmission by modulating action potential duration via BK channels
Loss of FMRP causes fragile X syndrome (FXS), but the physiological functions of FMRP
remain highly debatable. Here we show that FMRP regulates neurotransmitter release in …
remain highly debatable. Here we show that FMRP regulates neurotransmitter release in …
[HTML][HTML] The expanding social network of ionotropic glutamate receptors: TARPs and other transmembrane auxiliary subunits
AC Jackson, RA Nicoll - Neuron, 2011 - cell.com
Ionotropic glutamate receptors (iGluRs) underlie rapid, excitatory synaptic signaling
throughout the CNS. After years of intense research, our picture of iGluRs has evolved from …
throughout the CNS. After years of intense research, our picture of iGluRs has evolved from …
Mechanisms of action of antiseizure drugs and the ketogenic diet
MA Rogawski, W Löscher… - Cold Spring …, 2016 - perspectivesinmedicine.cshlp.org
Antiseizure drugs (ASDs), also termed antiepileptic drugs, are the main form of symptomatic
treatment for people with epilepsy, but not all patients become free of seizures. The …
treatment for people with epilepsy, but not all patients become free of seizures. The …