Protein splicing is a posttranslational process in which an intein segment excises itself from
two flanking peptides, referred to as exteins. In the native context, protein splicing results in …

Inteins are protein segments that are capable of enabling the ligation of flanking extein into a
new protein, a process known as protein splicing. Since its discovery, inteins have become …

The ability of biological systems to tightly regulate targeted variables, despite external and
internal disturbances, is known as Robust Perfect Adaptation (RPA). Achieved frequently …

Retinal gene therapy is a rapidly growing field with numerous clinical trials underway, and
route of delivery is a critical contributor to its success. Subretinal administration, which …

Retinal gene therapy has advanced considerably in the past three decades. Initial efforts
have been devoted to comprehensively explore and optimize the transduction abilities of …

Protein trans‐splicing catalyzed by split inteins has increasingly become useful as a protein
engineering tool. We solved the 1.0 Å‐resolution crystal structure of a fused variant from the …

Inteins are self-splicing protein elements found in viruses and all three domains of life. How
the DNA encoding these selfish elements spreads within and between genomes is poorly …

Background RNA trans-splicing joins exons from different pre-mRNA transcripts to generate
a chimeric product. Trans-splicing can also occur at the protein level, with split inteins …

The current trend in biopharmaceutical drug manufacturing is towards increasing potency
and complexity of products such as peptide scaffolds, oligonucleotides and many more …

In tervening pro teins, or inteins, are mobile genetic elements that are translated within host
polypeptides and removed at the protein level by splicing. In protein splicing, a self …