[HTML][HTML] Metabolic landscape in cardiac aging: insights into molecular biology and therapeutic implications

S Xie, SC Xu, W Deng, Q Tang - Signal transduction and targeted …, 2023 - nature.com
Cardiac aging is evident by a reduction in function which subsequently contributes to heart
failure. The metabolic microenvironment has been identified as a hallmark of malignancy …

Micronutrient deficiencies in heart failure: Mitochondrial dysfunction as a common pathophysiological mechanism?

N Bomer, MG Pavez‐Giani… - Journal of Internal …, 2022 - Wiley Online Library
Heart failure is a devastating clinical syndrome, but current therapies are unable to abolish
the disease burden. New strategies to treat or prevent heart failure are urgently needed …

[HTML][HTML] Assessment and management of statin-associated muscle symptoms (SAMS): A clinical perspective from the National Lipid Association

BA Warden, JR Guyton, AC Kovacs, JA Durham… - Journal of clinical …, 2023 - Elsevier
Statin-associated muscle symptoms (SAMS) are the most common form of statin intolerance
and are associated with increased risk of cardiovascular events that manifest from statin …

[HTML][HTML] 2023 Guidelines of the Taiwan Society of Cardiology on the diagnosis and management of chronic coronary syndrome

KC Ueng, CE Chiang, TH Chao, YW Wu… - Acta Cardiologica …, 2023 - ncbi.nlm.nih.gov
Coronary artery disease (CAD) covers a wide spectrum from persons who are asymptomatic
to those presenting with acute coronary syndromes (ACS) and sudden cardiac death …

[HTML][HTML] Coenzyme Q10 as adjunctive therapy for cardiovascular disease and hypertension: a systematic review

CB Sue-Ling, WM Abel, K Sue-Ling - The Journal of Nutrition, 2022 - Elsevier
Background Mitochondrial ATP production requires a small electron carrier, coenzyme Q 10
(CoQ 10), which has been used as adjunctive therapy in patients with cardiovascular …

[HTML][HTML] Dose-response effect of coenzyme Q10 supplementation on blood pressure among patients with cardiometabolic disorders: a grading of recommendations …

D Zhao, Y Liang, S Dai, S Hou, Z Liu, M Liu, X Dong… - Advances in …, 2022 - Elsevier
Previous studies have shown beneficial effects of coenzyme Q10 (CoQ10) supplementation
on blood pressure (BP). However, the optimal intake of CoQ10 for BP regulation in patients …

The activator protein-1 complex governs a vascular degenerative transcriptional programme in smooth muscle cells to trigger aortic dissection and rupture

Y Luo, J Luo, P An, Y Zhao, W Zhao… - European Heart …, 2024 - academic.oup.com
Abstract Background and Aims Stanford type A aortic dissection (AD) is a degenerative
aortic remodelling disease marked by an exceedingly high mortality without effective …

[HTML][HTML] Molecular mechanisms underlying the renal protective effects of coenzyme Q10 in acute kidney injury

S Zhao, W Wu, J Liao, X Zhang, M Shen, X Li… - Cellular & Molecular …, 2022 - Springer
Abstract Coenzyme Q10 (CoQ10), an endogenous antioxidant, has been reported frequently
to exert an outstanding protective effect on multiple organ injury, including acute kidney …

[HTML][HTML] Comparison of Coenzyme Q10 (Ubiquinone) and Reduced Coenzyme Q10 (Ubiquinol) as Supplement to Prevent Cardiovascular Disease and Reduce …

JP Fladerer, S Grollitsch - Current Cardiology Reports, 2023 - Springer
Abstract Purpose of Review According to the World Health Organization (WHO),
cardiovascular disease is the leading cause of death worldwide. Heart failure has been …

[HTML][HTML] Statins and cardiomyocyte metabolism, friend or foe?

T Somers, S Siddiqi, WJ Morshuis, FGM Russel… - Journal of …, 2023 - mdpi.com
Statins inhibit HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, and
are the cornerstone of lipid-lowering treatment. They significantly reduce cardiovascular …