In individual cells, transcription is a random process obeying single-molecule kinetics. Often,
it occurs in a bursty, intermittent manner. The frequency and size of these bursts affect the …

This review begins by briefly presenting the history of research on the chemical composition
and other parameters of cells of E. coli and S. enterica at different exponential growth rates …

Bacterial gene expression depends not only on specific regulatory mechanisms, but also on
bacterial growth, because important global parameters such as the abundance of RNA …

Gene activity is described by the time series of discrete, stochastic mRNA production events.
This transcriptional time series shows intermittent, bursty behavior. One consequence of this …

The term 'transcriptional interference'(TI) is widely used but poorly defined in the literature.
There are a variety of methods by which one can interfere with the process or the product of …

To determine the role of ppGpp in both negative and positive regulation of transcription
initiation during exponential growth in Escherichia coli, we examined transcription in …

Many photosynthetic organisms employ a CO2 concentrating mechanism (CCM) to increase
the rate of CO2 fixation via the Calvin cycle. CCMs catalyze≈ 50% of global photosynthesis …

In recent years, the number of recombinant proteins used for therapeutic applications has
increased dramatically. Production of these proteins has a remarkable demand in the …

Synthetic genetic systems share resources with the host, including machinery for
transcription and translation. Phage RNA polymerases (RNAP s) decouple transcription from …

Transcription networks consist of hundreds of transcription factors with thousands of often
overlapping target genes. While we can reliably measure gene expression changes, we still …