Efficacy of immunotherapy in oncogene-driven non-small-cell lung cancer
For advanced metastatic non-small-lung cancer, the landscape of actionable driver
alterations is rapidly growing, with nine targetable oncogenes and seven approvals within …
alterations is rapidly growing, with nine targetable oncogenes and seven approvals within …
Biomedical analysis of exosomes using biosensing methods: recent progress
HK Kordasht, M Hasanzadeh - Analytical methods, 2020 - pubs.rsc.org
Exosomes are membrane-bound extracellular vesicles (EVs) that are produced in the
endosomal compartments of most eukaryotic cells; they play important roles in intercellular …
endosomal compartments of most eukaryotic cells; they play important roles in intercellular …
Identification of Celastrol as a Novel YAP-TEAD Inhibitor for Cancer Therapy by High Throughput Screening with Ultrasensitive YAP/TAZ–TEAD Biosensors
The Hippo pathway has emerged as a key signaling pathway that regulates a broad range
of biological functions, and dysregulation of the Hippo pathway is a feature of a variety of …
of biological functions, and dysregulation of the Hippo pathway is a feature of a variety of …
Characterization of critical determinants of ACE2–SARS CoV-2 RBD interaction
Despite sequence similarity to SARS-CoV-1, SARS-CoV-2 has demonstrated greater
widespread virulence and unique challenges to researchers aiming to study its …
widespread virulence and unique challenges to researchers aiming to study its …
Circ0106714 inhibits tumorigenesis of colorectal cancer by sponging miR‐942‐5p and releasing DLG2 via Hippo‐YAP signaling
S Li, G Yan, W Liu, C Li, X Wang - Molecular Carcinogenesis, 2020 - Wiley Online Library
This study aimed to investigate the role of circ0106714‐miR‐942‐5p‐discs large homolog 2
(DLG2), a novel interactome, in colorectal cancer (CRC). Circ0106714 was found to be the …
(DLG2), a novel interactome, in colorectal cancer (CRC). Circ0106714 was found to be the …
Interplay of Developmental Hippo–Notch Signaling Pathways with the DNA Damage Response in Prostate Cancer
I Mourkioti, A Angelopoulou, K Belogiannis, N Lagopati… - Cells, 2022 - mdpi.com
Prostate cancer belongs in the class of hormone-dependent cancers, representing a major
cause of cancer incidence in men worldwide. Since upon disease onset almost all prostate …
cause of cancer incidence in men worldwide. Since upon disease onset almost all prostate …
Immunotherapy for ALK-Rearranged Non-Small Cell Lung Cancer: Challenges Inform Promising Approaches
Simple Summary Non-small cell lung cancer is the most common type of lung cancer.
Anaplastic Lymphoma Kinase (ALK) rearrangements have been found in 5–6% of non-small …
Anaplastic Lymphoma Kinase (ALK) rearrangements have been found in 5–6% of non-small …
Interaction of the Hippo pathway and phosphatases in tumorigenesis
S Sarmasti Emami, D Zhang, X Yang - Cancers, 2020 - mdpi.com
Simple Summary Recently, a group of genes called “Hippo” has been discovered that is
critical for the development and progression of a wide types of cancers. Therefore …
critical for the development and progression of a wide types of cancers. Therefore …
SARS-CoV-2 S1 NanoBiT: A nanoluciferase complementation-based biosensor to rapidly probe SARS-CoV-2 receptor recognition
As the COVID-19 pandemic continues, there is an imminent need for rapid diagnostic tools
and effective antivirals targeting SARS-CoV-2. We have developed a novel …
and effective antivirals targeting SARS-CoV-2. We have developed a novel …
Breast cancer tumor microenvironment and molecular aberrations hijack tumoricidal immunity
HJ Lin, Y Liu, D Lofland, J Lin - Cancers, 2022 - mdpi.com
Simple Summary Immune therapy is designed to stimulate tumoricidal effects in a variety of
solid tumors including breast carcinomas. However, the emergence of resistant clones leads …
solid tumors including breast carcinomas. However, the emergence of resistant clones leads …