Emerging roles of ALK in immunity and insights for immunotherapy

L Wang, VWY Lui - Cancers, 2020 - mdpi.com
Anaplastic lymphoma kinase (ALK) is mostly known for its oncogenic role in several human
cancers. Recent evidences clearly indicate new roles of ALK and its genetic aberrations (eg …

Targeting the Hippo pathway in prostate cancer: what's new?

K Coffey - Cancers, 2021 - mdpi.com
Simple Summary Prostate cancer is the most commonly diagnosed cancer in men in the UK,
accounting for the deaths of over 11,000 men per year. A major problem in this disease are …

Mst1/2-ALK promotes NLRP3 inflammasome activation and cell apoptosis during Listeria monocytogenes infection

A Gao, H Tang, Q Zhang, R Liu, L Wang, Y Liu… - Journal of …, 2021 - Springer
Listeria monocytogenes (L. monocytogenes) is a Gram-positive intracellular foodborne
pathogen that causes severe diseases, such as meningitis and sepsis. The NLR family pyrin …

Current status and challenges of immunotherapy in ALK rearranged NSCLC

R Qi, Y Yu, M Shen, D Lv, S He - Frontiers in oncology, 2022 - frontiersin.org
Rearrangements of the anaplastic lymphoma kinase (ALK) gene account for 5-6% in non-
small cell lung cancer (NSCLC). ALK rearranged NSCLC is sensitive to ALK tyrosine kinase …

[HTML][HTML] ALKAL1 gene silencing prevents colorectal cancer progression via suppressing Sonic Hedgehog (SHH) signaling pathway

S Chen, B Wang, X Fu, Y Liang, X Chai, Z Ye… - Journal of …, 2021 - ncbi.nlm.nih.gov
Anaplastic lymphoma kinase (ALK) has been described in a range of human cancers and is
involved in cancer initiation and progression via activating multiple signaling pathways, such …

Using Biosensors to Study Protein–Protein Interaction in the Hippo Pathway

A Pipchuk, X Yang - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
The Hippo signaling network is dependent on protein–protein interactions (PPIs) as a
mechanism of signal transduction to regulate organ size, cellular proliferation and …

Development of Novel Bioluminescent Biosensors Monitoring the Conformation and Activity of the Merlin Tumour Suppressor

A Pipchuk, T Kelly, M Carew, C Nicol… - International Journal of …, 2024 - mdpi.com
Solid tumours can universally evade contact inhibition of proliferation (CIP), a mechanism
halting cell proliferation when cell–cell contact occurs. Merlin, an ERM-like protein, crucially …

A high-throughput NanoBiT-based serological assay detects SARS-CoV-2 seroconversion

T Azad, R Rezaei, R Singaravelu, TR Jamieson… - Nanomaterials, 2021 - mdpi.com
High-throughput detection strategies for antibodies against SARS-CoV-2 in patients
recovering from COVID-19, or in vaccinated individuals, are urgently required during this …

[HTML][HTML] Robustness of NanoBiT luciferase complementation technology in the presence of widely used kinase inhibitors

TN Cartwright, SK Meyer, JMG Higgins - SLAS Discovery, 2022 - Elsevier
Bioluminescence assays using luciferase enzymes are widely used in research to monitor
gene expression and an array of other cell properties, and split luciferase enzymes can be …

Advanced Techniques for the Analysis of Proteins and RNAs

X Yang - Chemosensors, 2024 - mdpi.com
Proteins and RNAs, as fundamental components of cellular machinery, play pivotal roles in
the intricate landscape of life [1, 2]. They have a spectrum of functions, ranging from acting …