Karyotype complexity has major prognostic value in many malignancies. There is no
consensus on the definition of a complex karyotype, and the prognostic impact of karyotype …

Multiple studies have demonstrated the utility of chromosomal microarray (CMA) testing to
identify clinically significant copy number alterations (CNAs) and copy-neutral loss-of …

Abstract Purpose of Review Knowledge of both somatic mutations and copy number
aberrations are important for the understanding of cancer pathogenesis and management of …

Many patients referred to the hematological department with unexplained cytopenia are
diagnosed with idiopathic cytopenia of undetermined significance (ICUS) when diagnostic …

Aims The myelodysplastic syndromes (MDS) are a heterogeneous group of clonal
haematopoietic stem cell disorders characterised by inefficient haematopoiesis and risk of …

Introduction: Patients presenting with idiopathic cytopenia with non-diagnostic marrow
morphology and a normal karyotype pose a diagnostic and therapeutic challenge …

Myelodysplastic syndromes (MDS) are a group of heterogeneous hematologic diseases.
Chromosomal aberrations are important for the initiation, development, and progression of …

Background Myelodysplastic syndromes (MDS) encompass a group of heterogeneous
haematopoietic stem cell malignancies characterised by ineffective haematopoiesis …

Recent advancements in next-generation sequencing (NGS) technologies allow the
simultaneous identification of targeted copy number alterations (CNAs) as well as somatic …

Background: Chromosomal abnormalities play an important role in the diagnosis and
prognosis of patients with myelodysplastic syndromes (MDSs). The single-nucleotide …