[HTML][HTML] Extracellular vesicles: The next generation in gene therapy delivery

R Cecchin, Z Troyer, K Witwer, KV Morris - Molecular Therapy, 2023 - cell.com
Extracellular vesicles (EVs) are esteemed as a promising delivery vehicle for various genetic
therapeutics. They are relatively inert, non-immunogenic, biodegradable, and …

Exosomes based strategies for brain drug delivery

FU Rehman, Y Liu, M Zheng, B Shi - Biomaterials, 2023 - Elsevier
Exosome application has emerged as a promising nanotechnology discipline for various
diseases therapeutics and diagnoses. Owing to the natural properties of efficient drug …

[HTML][HTML] Exosome secreted from adipose-derived stem cells attenuates diabetic nephropathy by promoting autophagy flux and inhibiting apoptosis in podocyte

J Jin, Y Shi, J Gong, L Zhao, Y Li, Q He… - Stem cell research & …, 2019 - Springer
Background It is confirmed that adipose-derived stem cells (ADSCs) transplantation
effectively relieves kidney fibrosis and type 2 diabetes disease in mice. Currently, exosome …

Preservation and storage stability of extracellular vesicles for therapeutic applications

A Jeyaram, SM Jay - The AAPS journal, 2018 - Springer
Abstract Recently, extracellular vesicles (EVs)—including exosomes, microvesicles, and
others—have attracted interest as cell-derived biotherapeutics and drug delivery vehicles for …

Exosomes in cancer nanomedicine and immunotherapy: prospects and challenges

NL Syn, L Wang, EKH Chow, CT Lim, BC Goh - Trends in biotechnology, 2017 - cell.com
Exosomes (versatile, cell-derived nanovesicles naturally endowed with exquisite target-
homing specificity and the ability to surmount in vivo biological barriers) hold substantial …

[HTML][HTML] A call for the standardised reporting of factors affecting the exogenous loading of extracellular vesicles with therapeutic cargos

S Rankin-Turner, P Vader, L O'Driscoll, B Giebel… - Advanced drug delivery …, 2021 - Elsevier
Extracellular vesicles (EVs) are complex nanoparticles required for the intercellular transfer
of diverse biological cargoes. Unlike synthetic nanoparticles, EVs may provide a natural …

[HTML][HTML] Improved loading of plasma-derived extracellular vesicles to encapsulate antitumor miRNAs

MAC Pomatto, B Bussolati, S D'Antico, S Ghiotto… - … Therapy-Methods & …, 2019 - cell.com
Extracellular vesicles (EVs) carry various molecules involved in intercellular communication
and have raised great interest as drug delivery systems. Several engineering methods have …

[HTML][HTML] Therapeutic miRNA-enriched extracellular vesicles: current approaches and future prospects

J Munir, JK Yoon, S Ryu - Cells, 2020 - mdpi.com
Extracellular vesicles (EVs) are 50–300 nm vesicles secreted by eukaryotic cells. They can
carry cargo (including miRNA) from the donor cell to the recipient cell. miRNAs in EVs can …

Exosome-mediated delivery of RNA and DNA for gene therapy

R Munagala, F Aqil, J Jeyabalan, R Kandimalla… - Cancer letters, 2021 - Elsevier
Gene therapy promises to revolutionize biomedicine and personalized medicine by
modulating or compensating the expression of abnormal genes. The biggest obstacle for …

Milk/colostrum exosomes: A nanoplatform advancing delivery of cancer therapeutics

M Wallen, F Aqil, W Spencer, RC Gupta - Cancer Letters, 2023 - Elsevier
Chemotherapeutics continue to play a central role in the treatment of a wide variety of
cancers. Conventional chemotherapy involving bolus intravenous doses results in severe …