[HTML][HTML] Stem cell-derived extracellular vesicles in the therapeutic intervention of Alzheimer's Disease, Parkinson's Disease, and stroke

W Zhou, X Wang, Y Dong, P Gao, X Zhao, M Wang… - Theranostics, 2024 - ncbi.nlm.nih.gov
With the increase in the aging population, the occurrence of neurological disorders is rising.
Recently, stem cell therapy has garnered attention due to its convenient sourcing, minimal …

Non-pigmented ciliary epithelium-derived extracellular vesicles loaded with smad7 sirna attenuate wnt signaling in trabecular meshwork cells in vitro

S Tabak, V Feinshtein, S Schreiber-Avissar… - Pharmaceuticals, 2021 - mdpi.com
Primary open-angle glaucoma is established by the disruption of trabecular meshwork (TM)
function. The disruption leads to increased resistance to the aqueous humor (AH) …

Therapeutic application of small extracellular vesicles (sEVs): pharmaceutical and pharmacokinetic challenges

Y Takakura, A Matsumoto… - Biological and …, 2020 - jstage.jst.go.jp
Small extracellular vesicles (sEVs), including exosomes as typical example, are cell-derived
vesicles comprising lipid bilayer with a diameter approximately 100 nm. sEVs are …

Extracellular nanovesicles: from intercellular messengers to efficient drug delivery systems

SK Deshmukh, MA Khan, S Singh, AP Singh - ACS omega, 2021 - ACS Publications
Nanosized extracellular vesicles (nEV) are released by all the eukaryotic cells into the
extracellular spaces. They serve as crucial mediators of intercellular communication, and …

Exosomes as new generation vehicles for drug delivery systems

N Dilsiz - Journal of Drug Delivery Science and Technology, 2024 - Elsevier
Exosomes are the smallest subtype of mobile extracellular vesicles (EVs), and round sacs
with a diameter between 30 and 120 nm are released by almost all cell types into the …

Advancement in exosome-based cancer therapeutics: A new era in cancer treatment

A Dutta, S Paul - Frontiers in Nanotechnology, 2022 - frontiersin.org
In the modern era of rapid development and advancement in cancer therapeutics and
management, there is a growing awareness in the application of exosomes as a potential …

Effective exosomes in breast cancer: Focusing on diagnosis and treatment of cancer progression

B Abdullaev, SA Rasyid, E Ali, AMB Al-Dhalimy… - … -Research and Practice, 2023 - Elsevier
Breast cancer (BC) is the most prevalent aggressive malignant tumor in women worldwide
and develops from breast tissue. Although cutting-edge treatment methods have been used …

Engineering of exosomes: steps towards green production of drug delivery system

AY Sherif, GI Harisa, FK Alanazi… - Current Drug …, 2019 - ingentaconnect.com
Targeting of therapeutic agents to their specific site of action not only increases the treatment
efficacy, but also reduces systemic toxicity. Therefore, various drug delivery systems (DDSs) …

Harnessing the therapeutic potential of extracellular vesicles for cancer treatment

Y Zhang, Y Xiao, G Sun, X Jin, L Guo, T Li… - Seminars in Cancer …, 2021 - Elsevier
Cancer therapeutic strategies include surgeries, radiotherapy, chemotherapy, targeted
therapy and immunotherapies. However, current cancer treatment still faces challenges …

Small extracellular vesicles loaded with immunosuppressive miRNAs leads to an inhibition of dendritic cell maturation

L Czernek, Ł Pęczek, M Düchler - Archivum Immunologiae et Therapiae …, 2022 - Springer
In particular conditions, inhibition of an immune response is required to prevent tissue
damage. Among these conditions are diseases caused by an over-reactive immune …