PET parametric imaging: past, present, and future
Positron emission tomography (PET) is actively used in a diverse range of applications in
oncology, cardiology, and neurology. The use of PET in the clinical setting focuses on static …
oncology, cardiology, and neurology. The use of PET in the clinical setting focuses on static …
PET image denoising based on denoising diffusion probabilistic model
Purpose Due to various physical degradation factors and limited counts received, PET
image quality needs further improvements. The denoising diffusion probabilistic model …
image quality needs further improvements. The denoising diffusion probabilistic model …
Intrinsic, widefield optical imaging of hemodynamics in rodent models of Alzheimer's disease and neurological injury
The complex cerebrovascular network is critical to controlling local cerebral blood flow
(CBF) and maintaining brain homeostasis. Alzheimer's disease (AD) and neurological injury …
(CBF) and maintaining brain homeostasis. Alzheimer's disease (AD) and neurological injury …
Spatial decrease of synaptic density in amnestic mild cognitive impairment follows the tau build-up pattern
G Vanderlinden, J Ceccarini, T Vande Casteele… - Molecular …, 2022 - nature.com
Next to amyloid and tau, synaptic loss is a key pathological hallmark in Alzheimer's disease,
closely related to cognitive dysfunction and neurodegeneration. Tau is thought to cause …
closely related to cognitive dysfunction and neurodegeneration. Tau is thought to cause …
Amyloid, tau and metabolic PET correlates of cognition in early and late-onset Alzheimer's disease
Abstract Early-onset (age< 65) Alzheimer's disease is associated with greater non-amnestic
cognitive symptoms and neuropathological burden than late-onset disease. It is not fully …
cognitive symptoms and neuropathological burden than late-onset disease. It is not fully …
Regional tau effects on prospective cognitive change in cognitively normal older adults
Studies suggest that tau deposition starts in the anterolateral entorhinal cortex (EC) with
normal aging, and that the presence of β-amyloid (Aβ) facilitates its spread to neocortex …
normal aging, and that the presence of β-amyloid (Aβ) facilitates its spread to neocortex …
Genetically identical twins show comparable tau PET load and spatial distribution
EM Coomans, J Tomassen, R Ossenkoppele… - Brain, 2022 - academic.oup.com
Tau accumulation starts during the preclinical phase of Alzheimer's disease and is closely
associated with cognitive decline. For preventive purposes, it is important to identify factors …
associated with cognitive decline. For preventive purposes, it is important to identify factors …
[HTML][HTML] Evaluation of whole-brain oxygen metabolism in Alzheimer's disease using QSM and quantitative BOLD
Objective The objective of this study was to evaluate the whole-brain pattern of oxygen
extraction fraction (OEF), cerebral blood flow (CBF), and cerebral metabolic rate of oxygen …
extraction fraction (OEF), cerebral blood flow (CBF), and cerebral metabolic rate of oxygen …
[HTML][HTML] Differential associations between neocortical tau pathology and blood flow with cognitive deficits in early-onset vs late-onset Alzheimer's disease
D Visser, SCJ Verfaillie, EE Wolters… - European journal of …, 2022 - Springer
Abstract Purpose Early-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's
disease (LOAD) differ in neuropathological burden and type of cognitive deficits. Assessing …
disease (LOAD) differ in neuropathological burden and type of cognitive deficits. Assessing …
[HTML][HTML] Spatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition
Autopsy studies indicated that the locus coeruleus (LC) accumulates hyperphosphorylated
tau before allocortical regions in Alzheimer's disease. By combining in vivo longitudinal …
tau before allocortical regions in Alzheimer's disease. By combining in vivo longitudinal …