Migraine is a primary headache disorder characterized by a unilateral, throbbing, pulsing
headache, which lasts for hours to days, and the pain can interfere with daily activities. It …

Calcitonin gene-related peptide (CGRP), a 37 amino-acid neuropeptide found mostly in
peptidergic sensory C-fibers, has been suggested to be implicated in the pathogenesis of …

Accumulating evidence suggests the key role of the kynurenine pathway (KP) of the
tryptophan metabolism in the pathogenesis of several diseases. Despite extensive research …

Chronic pain is an unpleasant sensory and emotional experience that persists or recurs
more than three months and may extend beyond the expected time of healing. Recently …

Transient receptor potential ankyrin 1 (TRPA1) plays a role in migraine and is proposed as a
promising target for migraine therapy. However, TRPA1-induced signaling in migraine …

Migraine is a neurological disease that affects approximately one billion of individuals
worldwide, and has been considered by the Global Burden of Diseases 2019 as the second …

Abstract Italian Migraine Registry (I-GRAINE) is a multicenter (n= 38), prospective,
observational, non-interventional study aimed at providing big data on migraine to ensure …

Objective To gather information about prescription of triptans and to evaluate whether
vascular comorbidity differs in users and nonusers of triptans over the age of 50 years …

In recent years there has been a flurry of novel antimigraine treatments targeting specific
pathways that have been shown to be involved in its pathophysiology, like the calcitonin …

Despite all studies during the last decades, the exact pathophysiological mechanisms
underlying the onset of a migraine attack are not yet fully characterized. Notwithstanding, the …