The industrial activities of the last century have caused massive increases in human
exposure to heavy metals. Mercury, lead, chromium, cadmium, and arsenic have been the …

Nickel is a transition element extensively distributed in the environment, air, water, and soil.
It may derive from natural sources and anthropogenic activity. Although nickel is ubiquitous …

Many metals are essential for living organisms, but at higher doses they may be toxic and
carcinogenic. Metal exposure occurs mainly in occupational settings and environmental …

Long-term exposure to arsenic (inorganic arsenic) is a world-wide environmental health
concern. Arsenic is classified as the Group 1 human carcinogen by the International Agency …

Over the years, anthropogenic factors have led to cadmium (Cd) accumulation in the
environment causing various health problems in humans. Although Cd is not a Fenton-like …

Humic substances (HSs) have considerable effects on soil fertility and crop productivity
owing to their unique physiochemical and biochemical properties, and play a vital role in …

Nutritional factors play a life-long role in human health. Indeed, there is growing evidence
that one of the mechanisms by which nutrients and bioactive compounds affect metabolic …

This review focuses on how environmental factors through epigenetics modify disease risk
and health outcomes. Major epigenetic events, such as histone modifications, DNA …

The key characteristics (KC) of human carcinogens provide a uniform approach to
evaluating mechanistic evidence in cancer hazard identification. Refinements to the …

Current evidence supports the notion that environmental exposures are associated with
DNA-methylation and expression changes that can impact human health. Our objective was …