Neurosteroids and the mesocorticolimbic system

DR Seib, DJ Tobiansky, J Meitzen, SB Floresco… - Neuroscience & …, 2023 - Elsevier
The mesocorticolimbic system coordinates executive functions, such as working memory
and behavioral flexibility. This circuit includes dopaminergic projections from the ventral …

Executive function in obesity and anorexia nervosa: Opposite ends of a spectrum of disordered feeding behaviour?

CJ Foldi, MJ Morris, BJ Oldfield - Progress in Neuro-Psychopharmacology …, 2021 - Elsevier
Higher-order executive functions such as decision-making, cognitive flexibility and
behavioural control are critical to adaptive success in all aspects of life, including the …

Neural mechanisms mediating sex differences in motivation for reward: cognitive bias, food, gambling, and drugs of abuse

CA Orsini, TE Brown, TE Hodges… - Journal of …, 2022 - Soc Neuroscience
Sex differences in motivation for food rewards, gambling, and drugs of abuse are modulated
by multiple factors, including sensory stimuli, gonadal hormones, and cognitive bias. Cues …

Noradrenergic contributions to cue-driven risk-taking and impulsivity

CS Chernoff, TJ Hynes, CA Winstanley - Psychopharmacology, 2021 - Springer
Rationale The flashing lights and sounds of modern casinos are alluring and may contribute
to the addictive nature of gambling. Such cues can have a profound impact on the …

Dopamine neurons gate the intersection of cocaine use, decision making, and impulsivity

TJ Hynes, KM Hrelja, BA Hathaway… - Addiction …, 2021 - Wiley Online Library
Gambling and substance use disorders are highly comorbid. Both clinical populations are
impulsive and exhibit risky decision‐making. Drug‐associated cues have long been known …

Pharmacological evidence of a cholinergic contribution to elevated impulsivity and risky decision-making caused by adding win-paired cues to a rat gambling task

GD Betts, TJ Hynes… - Journal of …, 2021 - journals.sagepub.com
Background: Pairing rewards with sensory stimulation, in the form of auditory and visual
cues, increases risky decision-making in both rats and humans. Understanding the …

Sex differences in risk-based decision-making and the modulation of risk preference by dopamine-2 like receptors in rats

SM Ayoub, AM Libster, SA Barnes, SC Dulawa… - …, 2024 - Elsevier
Heightened risk-based decision-making is observed across several neuropsychiatric
disorders including schizophrenia, bipolar disorder, and Parkinson's disease, yet no …

[HTML][HTML] Propensity for risky choices despite lower cue reactivity in adolescent rats

S Zeng, EFB McLaughlin, A Ramesh… - Frontiers in Behavioral …, 2023 - frontiersin.org
Adolescence is a time of heightened risk-taking across species. Salient audiovisual cues
associated with rewards are a common feature of gambling environments and have been …

Dissociable roles of the mPFC-to-VTA Pathway in the control of Impulsive Action and Risk-Related Decision-Making in Roman High-And Low-Avoidance Rats

G Urueña-Méndez, C Arrondeau… - International Journal …, 2024 - academic.oup.com
Background Impulsive action and risk-related decision-making (RDM) are associated with
various psychiatric disorders including drug abuse. Both behavioral traits have also been …

[HTML][HTML] Acute and chronic effects by nicotine on striatal neurotransmission and synaptic plasticity in the female rat brain

E Lucente, B Söderpalm, M Ericson… - Frontiers in Molecular …, 2023 - frontiersin.org
Introduction Tobacco use is in part a gendered activity, yet neurobiological studies outlining
the effect by nicotine on the female brain are scarce. The aim of this study was to outline …