Autoimmune rheumatic diseases are characterised by an autoimmune inflammatory
response to antigens of synovial tissue, muscles, and other organs. While the prognosis of …

Shortly after diagnosis of type 1 diabetes mellitus (T1DM) and initiation of insulin therapy,
many patients experience a transient partial remission (PR) phase, also known as the …

Background Short-chain fatty acids (SCFAs) produced by the gut microbiota have beneficial
anti-inflammatory and gut homeostasis effects and prevent type 1 diabetes (T1D) in mice …

T cell receptor (TCR) sequences are exceptionally diverse and can now be
comprehensively measured with next-generation sequencing technologies. However, a …

Soon after diagnosis with type 1 diabetes (T1D), many patients experience a period of
partial remission. A longer partial remission is associated with a better response to …

Dendritic cells (DCs) are professional antigen-presenting cells and trigger downstream
immune responses to antigen while integrating cellular pathogen and damage-associated …

BACKGROUND Antigen-specific regulation of autoimmune disease is a major goal. In
seropositive rheumatoid arthritis (RA), T cell help to autoreactive B cells matures the …

Type 1 diabetes (T1D) is a chronic autoimmune disorder in which b-cell destruction occurs
leading to the body's inability to make adequate insulin. 1, 2 According to the SEARCH …

The current standard of care for type 1 diabetes patients is limited to treatment of the
symptoms of the disease, insulin insufficiency and its complications, not its cause. Given the …

Context Aberrant biosynthesis and secretion of the insulin precursor proinsulin occurs in
both type I and type II diabetes. Inflammatory cytokines are implicated in pancreatic islet …