Adolescence is a significant period of physical, social, and emotional development, and is
characterized by prominent neurobiological changes in the brain. The maturational …

Cognition underpins the flexibility of human eating and disruption to higher cognitive
processes, such as inhibitory control and memory, and can result in increased food intake …

Obesity is a global health problem with high prevalence and defined by a high body mass
index (BMI). Several comorbidities affecting the central nervous system (CNS) are …

Consumption of poor nutrients diets is associated with fat tissue expansion and with a
central and peripheral low-grade inflammation. In this sense, the microglial cells in the …

Emergent evidence demonstrates that excessive consumption of high fat and high sugar
(HFHS) diets has negative consequences on hippocampal and prefrontal cortex (PFC) …

Fear-related disorders arise from inefficient fear extinction and have immeasurable social
and economic costs. Here, we characterize mouse phenotypes that spontaneously show …

Brain plasticity is a multifaceted process that is dependent on both neurons and extracellular
matrix (ECM) structures, including perineuronal nets (PNNs). In the medial prefrontal cortex …

Early life, covering childhood and adolescence in humans, is an important period of brain
development and maturation. Experimental works in rodents have shown that high-caloric …

Maternal hypercaloric exposure during pregnancy and lactation is a risk factor for
developing diseases associated with inflammation such as obesity, diabetes and …

Psychiatric conditions marked by impairments in cognitive control often emerge during
adolescence, when the prefrontal cortex (PFC) and its inputs undergo structural and …