[HTML][HTML] Anticancer therapeutic potential of benzofuran scaffolds
Benzofuran moiety is the main component of many biologically active natural and synthetic
heterocycles. These heterocycles have unique therapeutic potentials and are involved in …
heterocycles. These heterocycles have unique therapeutic potentials and are involved in …
Structural insights of oxindole based kinase inhibitors as anticancer agents: Recent advances
P Dhokne, AP Sakla, N Shankaraiah - European journal of medicinal …, 2021 - Elsevier
Small-molecule kinase inhibitors are being continuously explored as new anticancer
therapeutics. Kinases are the phosphorylating enzymes which regulate numerous cellular …
therapeutics. Kinases are the phosphorylating enzymes which regulate numerous cellular …
[HTML][HTML] Design and Synthesis of New Quinoxaline Derivatives as Potential Histone Deacetylase Inhibitors Targeting Hepatocellular Carcinoma: In Silico, In Vitro …
C Ma, MS Taghour, A Belal, ABM Mehany… - Frontiers in …, 2021 - frontiersin.org
Guided by the structural optimization principle and the promising anticancer effect of the
quinoxaline nucleus, a new series of novel HDAC inhibitors were designed and …
quinoxaline nucleus, a new series of novel HDAC inhibitors were designed and …
Design, synthesis and molecular docking of new fused 1H-pyrroles, pyrrolo[3,2-d]pyrimidines and pyrrolo[3,2-e][1, 4]diazepine derivatives as potent EGFR/CDK2 …
A Belal, NM Abdel Gawad, ABM Mehany… - Journal of enzyme …, 2022 - Taylor & Francis
A new series of 1 H-pyrrole (6a–c, 8a–c), pyrrolo [3, 2-d] pyrimidines (9a–c) and pyrrolo [3, 2-
e][1, 4] diazepines (11a–c) were designed and synthesised. These compounds were …
e][1, 4] diazepines (11a–c) were designed and synthesised. These compounds were …
Novel benzothiazole-based dual VEGFR-2/EGFR inhibitors targeting breast and liver cancers: Synthesis, cytotoxic activity, QSAR and molecular docking studies
EA Abd El-Meguid, AM Naglah, GO Moustafa… - Bioorganic & Medicinal …, 2022 - Elsevier
A novel series of benzothiazole-based derivatives linked to various amino acids and their
corresponding ethyl ester analogues were prepared and were initially evaluated for their …
corresponding ethyl ester analogues were prepared and were initially evaluated for their …
Anti-cancer and immunomodulatory evaluation of new nicotinamide derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: in vitro and in silico studies
Abstract New nicotinamide derivatives 6, 7, 10, and 11 were designed and synthesised
based on the essential features of the VEGFR-2 inhibitors. Compound 10 revealed the …
based on the essential features of the VEGFR-2 inhibitors. Compound 10 revealed the …
[HTML][HTML] Discovery of new VEGFR-2 inhibitors: design, synthesis, anti-proliferative evaluation, docking, and MD simulation studies
EB Elkaeed, RG Yousef, MM Khalifa, A Ibrahim… - Molecules, 2022 - mdpi.com
Four new nicotinamide-based derivatives were designed as antiangiogenic VEGFR-2
inhibitors. The congeners were synthesized possessing the pharmacophoric essential …
inhibitors. The congeners were synthesized possessing the pharmacophoric essential …
[HTML][HTML] Computer-aided drug design in anti-cancer drug discovery: what have we learnt and what is the way forward??
The escalating prevalence of cancer on a global scale, coupled with the inadequacies of
present-day therapies and the emergence of drug-resistant cancer strains, has necessitated …
present-day therapies and the emergence of drug-resistant cancer strains, has necessitated …
Development of novel benzofuran-based SLC-0111 analogs as selective cancer-associated carbonic anhydrase isoform IX inhibitors
In the present study, we describe the design of different series of benzofuran-based
derivatives as potential carbonic anhydrase inhibitors (CAIs). The adopted design is based …
derivatives as potential carbonic anhydrase inhibitors (CAIs). The adopted design is based …
Identification of 3-(piperazinylmethyl)benzofuran derivatives as novel type II CDK2 inhibitors: design, synthesis, biological evaluation, and in silico insights
In the current work, a hybridisation strategy was adopted between the privileged building
blocks, benzofuran and piperazine, with the aim of designing novel CDK2 type II inhibitors …
blocks, benzofuran and piperazine, with the aim of designing novel CDK2 type II inhibitors …