Alcohol dehydrogenases, aldehyde dehydrogenases, and alcohol use disorders: a critical review
HJ Edenberg, JN McClintick - Alcoholism: Clinical and …, 2018 - Wiley Online Library
Alcohol use disorders (AUDs) are complex traits, meaning that variations in many genes
contribute to the risk, as does the environment. Although the total genetic contribution to risk …
contribute to the risk, as does the environment. Although the total genetic contribution to risk …
Less drinking, yet more problems: understanding African American drinking and related problems.
Researchers have found that, compared to European Americans, African Americans report
later initiation of drinking, lower rates of use, and lower levels of use across almost all age …
later initiation of drinking, lower rates of use, and lower levels of use across almost all age …
Genome-wide association study of alcohol dependence
J Treutlein, S Cichon, M Ridinger… - Archives of general …, 2009 - jamanetwork.com
Context Alcohol dependence is a serious and common public health problem. It is well
established that genetic factors play a major role in the development of this disorder …
established that genetic factors play a major role in the development of this disorder …
The genetics of addiction—a translational perspective
Addictions are serious and common psychiatric disorders, and are among the leading
contributors to preventable death. This selective review outlines and highlights the need for …
contributors to preventable death. This selective review outlines and highlights the need for …
Refined Geographic Distribution of the Oriental ALDH2*504Lys (nee 487Lys) Variant
H Li, S Borinskaya, K Yoshimura… - Annals of human …, 2009 - Wiley Online Library
Mitochondrial aldehyde dehydrogenase (ALDH2) is one of the most important enzymes in
human alcohol metabolism. The oriental ALDH2* 504Lys variant functions as a dominant …
human alcohol metabolism. The oriental ALDH2* 504Lys variant functions as a dominant …
[HTML][HTML] Biology, genetics, and environment: underlying factors influencing alcohol metabolism
Gene variants encoding several of the alcohol-metabolizing enzymes, alcohol
dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), are among the largest …
dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), are among the largest …
A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium
JD McKay, T Truong, V Gaborieau, A Chabrier… - PLoS …, 2011 - journals.plos.org
Genome-wide association studies (GWAS) have been successful in identifying common
genetic variation involved in susceptibility to etiologically complex disease. We conducted a …
genetic variation involved in susceptibility to etiologically complex disease. We conducted a …
Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis
S Macgregor, PA Lind, KK Bucholz… - Human molecular …, 2009 - academic.oup.com
Alcohol dependence (AD) is a complex disorder with environmental and genetic origins. The
role of two genetic variants in ALDH2 and ADH1B in AD risk has been extensively …
role of two genetic variants in ALDH2 and ADH1B in AD risk has been extensively …
Strong association of the alcohol dehydrogenase 1B gene (ADH1B) with alcohol dependence and alcohol-induced medical diseases
BACKGROUND: The alcohol dehydrogenase 1B gene (ADH1B) is hypothesized to affect
predisposition to alcohol dependence (AD) and abuse. A variant of the ADH1B gene …
predisposition to alcohol dependence (AD) and abuse. A variant of the ADH1B gene …
Generalized genomic distance–based regression methodology for multilocus association analysis
J Wessel, NJ Schork - The American Journal of Human Genetics, 2006 - cell.com
Large-scale, multilocus genetic association studies require powerful and appropriate
statistical-analysis tools that are designed to relate genotype and haplotype information to …
statistical-analysis tools that are designed to relate genotype and haplotype information to …