Lipoprotein-based drug delivery

S Busatto, SA Walker, W Grayson, A Pham… - Advanced drug delivery …, 2020 - Elsevier
Lipoproteins (LPs) are circulating heterogeneous nanoparticles produced by the liver and
intestines. LPs play a major role in the transport of dietary and endogenous lipids to target …

Polymeric nanoparticle mediated inhibition of miR-21 with enhanced miR-124 expression for combinatorial glioblastoma therapy

Y Liu, M Zheng, M Jiao, C Yan, S Xu, Q Du, M Morsch… - Biomaterials, 2021 - Elsevier
Glioblastoma (GBM) is the most common and fatal form of malignant brain tumor. Despite
intensive effort, there is still no effective GBM treatment. Therefore, novel and more effective …

Nanocarriers for microRNA delivery in cancer medicine

I Fernandez-Piñeiro, I Badiola, A Sanchez - Biotechnology advances, 2017 - Elsevier
The number of deaths caused by cancer is expected to increase partly due to the lack of
selectivity and undesirable systemic effects of current treatments. Advances in the …

Extracellular miRNAs as mediators of obesity‐associated disease

BB Brandao, M Lino, CR Kahn - The Journal of physiology, 2022 - Wiley Online Library
Extracellular miRNAs are found in a variety of body fluids and mediate intercellular and
interorgan communication, thus regulating gene expression and cellular metabolism. These …

Regulation of adipogenesis by exosomal milk miRNA

MA Abbas, NN Al-Saigh, FG Saqallah - Reviews in Endocrine and …, 2023 - Springer
Milk is a rich source of miRNA packaged in exosomes. Evidence for the systemic uptake and
tissue distribution of milk exosomes was reported in newborn and adult humans and …

Role of noncoding RNAs in the pathogenesis of abdominal aortic aneurysm: possible therapeutic targets?

S Kumar, RA Boon, L Maegdefessel… - Circulation …, 2019 - Am Heart Assoc
Abdominal aortic aneurysm (AAA) is a local dilatation of the abdominal aortic vessel wall
and is among the most challenging cardiovascular diseases as without urgent surgical …

Folic‐acid‐mediated functionalized gold nanocages for targeted delivery of anti‐miR‐181b in combination of gene therapy and photothermal therapy against …

S Huang, S Duan, J Wang, S Bao, X Qiu… - Advanced Functional …, 2016 - Wiley Online Library
Therapeutic strategies based on modulation of microRNAs (miRNAs) activity hold much
promise for cancer therapy, but for clinical applications, the efficient delivery of miRNAs to …

Designing electrospun fiber platforms for efficient delivery of genetic material and genome editing tools

DL Puhl, D Mohanraj, DW Nelson, RJ Gilbert - Advanced drug delivery …, 2022 - Elsevier
Electrospun fibers are versatile biomaterial platforms with great potential to support
regeneration. Electrospun fiber characteristics such as fiber diameter, degree of alignment …

Exosomes: Nanoparticulate tools for RNA interference and drug delivery

F Shahabipour, N Barati, TP Johnston… - Journal of cellular …, 2017 - Wiley Online Library
Exosomes are naturally occurring extracellular vesicles released by most mammalian cells
in all body fluids. Exosomes are known as key mediators in cell‐cell communication and …

The emerging role of miRNAs in inflammatory bowel disease: a review

CG Chapman, J Pekow - Therapeutic advances in …, 2015 - journals.sagepub.com
Inflammatory bowel disease (IBD), comprised of ulcerative colitis and Crohn's disease, is
believed to develop as a result of a deregulated inflammatory response to environmental …