Emerging mechanisms of pulmonary vasoconstriction in SARS-CoV-2-induced acute respiratory distress syndrome (ARDS) and potential therapeutic targets
H Karmouty-Quintana, RA Thandavarayan… - International journal of …, 2020 - mdpi.com
The 1918 influenza killed approximately 50 million people in a few short years, and now, the
world is facing another pandemic. In December 2019, a novel coronavirus named severe …
world is facing another pandemic. In December 2019, a novel coronavirus named severe …
Dysregulated Bradykinin: Mystery in the Pathogenesis of COVID‐19
The COVID‐19 pandemic is rapidly spreading, and health care systems are being
overwhelmed with the huge number of cases, with a good number of cases requiring …
overwhelmed with the huge number of cases, with a good number of cases requiring …
Methylene blue may have a role in the treatment of COVID-19
SM Ghahestani, E Shahab, S Karimi, MH Madani - Medical hypotheses, 2020 - Elsevier
In this paper, we raise the hypothesis that Methylene Blue may be a treatment option for
Corona Virus Disease of 2019 specially when combined with Non Steroid Anti-Inflammatory …
Corona Virus Disease of 2019 specially when combined with Non Steroid Anti-Inflammatory …
Aprotinin (II): Inhalational Administration for the Treatment of COVID-19 and Other Viral Conditions
JF Padín, JM Pérez-Ortiz… - International Journal of …, 2024 - mdpi.com
Aprotinin is a broad-spectrum inhibitor of human proteases that has been approved for the
treatment of bleeding in single coronary artery bypass surgery because of its potent …
treatment of bleeding in single coronary artery bypass surgery because of its potent …
Indomethacin: can it counteract bradykinin effects in COVID-19 patients?
M Alkotaji, RN Al-Zidan - Current Pharmacology Reports, 2021 - Springer
COVID-19 represents the biggest health challenge. Although the mortality rate of COVID-19
is low, the high numbers of infected people and those with post-COVID-19 symptoms …
is low, the high numbers of infected people and those with post-COVID-19 symptoms …
Brain Renin–Angiotensin System: From Physiology to Pathology in Neuronal Complications Induced by SARS‐CoV‐2
S Ahmadi, S Khaledi - Analytical Cellular Pathology, 2023 - Wiley Online Library
Angiotensin‐converting enzyme 2 (ACE2), a key enzyme in the renin–angiotensin system
(RAS), is expressed in various tissues and organs, including the central nervous system …
(RAS), is expressed in various tissues and organs, including the central nervous system …
Process intensification for the purification of peptidomimetics: the case of icatibant through multicolumn countercurrent solvent gradient purification (MCSGP)
C De Luca, S Felletti, D Bozza, G Lievore… - Industrial & …, 2021 - ACS Publications
Biopharmaceuticals are subjected to very strict purity requirements to be marketed. At the
same time, peptides and other biomolecules are industrially synthesized through techniques …
same time, peptides and other biomolecules are industrially synthesized through techniques …
An updated review on complicated mechanisms of COVID-19 pathogenesis and therapy: direct viral damage, renin-angiotensin system dysregulation, immune system …
SARS-CoV-2 was reported as the cause of coronavirus disease 2019 (COVID-19) in late
December 2019. According to sequencing and phylogenetic studies, the new virus belongs …
December 2019. According to sequencing and phylogenetic studies, the new virus belongs …
[HTML][HTML] Aprotinin (I): Understanding the Role of Host Proteases in COVID-19 and the Importance of Pharmacologically Regulating Their Function
JF Padín, JM Pérez-Ortiz… - International Journal of …, 2024 - mdpi.com
Proteases are produced and released in the mucosal cells of the respiratory tract and have
important physiological functions, for example, maintaining airway humidification to allow …
important physiological functions, for example, maintaining airway humidification to allow …
[HTML][HTML] Long and short-term metformin consumption as a potential therapy to prevent complications of COVID-19
E Shaseb, S Ghaffary, A Garjani, E Zoghi… - Advanced …, 2023 - ncbi.nlm.nih.gov
Purpose: The aim of the study is to evaluate the effect of metformin in complication
improvement of hospitalized patients with COVID-19. Methods: This was a randomized …
improvement of hospitalized patients with COVID-19. Methods: This was a randomized …