BACKGROUND:: Psychomotor stimulant drugs such as cocaine and amphetamine activate
brain dopamine (DA) neurotransmission and support self-administration in humans and …

The acute and chronic effects of abused psychostimulants on monoamine transporters and
associated neurobiology have encouraged development of candidate medications that …

A prominent aspect of drug addiction is the ability of drug-associated cues to elicit craving
and facilitate relapse. Understanding the factors that regulate cue reactivity will be vital for …

Transporters of dopamine, serotonin, and norepinephrine have been empirically used as
medication targets for several mental illnesses in the last decades. These protein-targeted …

Rationale The reinforcing effects of cocaine are mediated by the mesolimbic dopamine
system. Behavioral and neurochemical studies have shown that the cholinergic muscarinic …

Much effort has been devoted to research focused on pharmacotherapies for cocaine
dependence yet there are no FDA-approved medications for this brain disease. Preclinical …

Rationale Few effective treatments exist for cocaine use disorders due to gaps in knowledge
about its complex etiology. Genetically defined animal models provide a useful tool for …

The subjective effects of intravenous cocaine are felt almost immediately, and this
immediacy plays an important part in the drug's rewarding impact. The primary rewarding …

Although the dopamine transporter (DAT) is the primary site of action for cocaine, and the
dopamine system is known to mediate the reinforcing effects of cocaine, the dopaminergic …

Preclinical investigations have demonstrated that drugs of abuse alter the levels of lipid-
based signalling molecules, including endocannabinoids (eCBs) and N-acylethanolamines …