Purpose Laryngopharyngeal reflux disease (LPRD) is a general term for the reflux of
gastroduodenal contents into the laryngopharynx, oropharynx and even the nasopharynx …

Colorectal Cancer (CRC), a common malignancy, is developing globally among people.
Mutagenic insults activate peripheral nucleated cells to secrete chemokines in order to …

质子泵抑制剂对咽喉反流患者唾液胃蛋白酶浓度的影响- PMC Back to Top Skip to main content NIH
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Objective Laryngopharyngeal reflux (LPR) is a common affliction that contributes to
laryngeal inflammation, symptoms that impact quality of life, and life‐threatening illnesses …

Progress continues to be made in our understanding of pepsin-mediated damage with
implications for novel therapeutic strategies. Salivary pepsin diagnostics continue to garner …

The upper aerodigestive tract (UAT) is the first line of defense against environmental
stresses such as antigens, microbes, inhalants, foods, etc., and mucins, intracellular …

Pepsin refluxate is considered a risk factor for laryngopharyngeal carcinogenesis. Non-
acidic pepsin was previously linked to an inflammatory and tumorigenic effect on …

Objective Numerous meta-analyses have revealed the association between gastro-
oesophageal reflux disease (GORD) and a range of diseases; however, the certainty of the …

Airway reflux is implicated in the pathophysiology of a wide range of adult and pediatric
upper and lower airway diseases. However, the diagnosis of proximal reflux–associated …

Objective More than 20% of the US population suffers from laryngopharyngeal reflux.
Although dietary/lifestyle modifications and alginates provide benefit to some, there is no …