Traditional uses, ten-years research progress on phytochemistry and pharmacology, and clinical studies of the genus Scutellaria

J Shen, P Li, S Liu, Q Liu, Y Li, Y Sun, C He… - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance Scutellaria (Lamiaceae), which includes
approximately 360–469 accepted species, is widespread in Europe, North America, East …

Promising influences of Scutellaria baicalensis and its two active constituents, baicalin, and baicalein, against metabolic syndrome: A review

V Baradaran Rahimi, VR Askari… - Phytotherapy …, 2021 - Wiley Online Library
Metabolic syndrome is known as a group of metabolic abnormalities with features including
central obesity, insulin resistance, hypercholesterolemia, hypertriglyceridemia, and …

[HTML][HTML] Composite probiotics alleviate type 2 diabetes by regulating intestinal microbiota and inducing GLP-1 secretion in db/db mice

Y Wang, D Dilidaxi, Y Wu, J Sailike, X Sun… - Biomedicine & …, 2020 - Elsevier
Abstract Backgroud/Aim Previous studies have found that probiotic fermented camel milk
has anti-diabetic effect by inducing (glucagon-like peptide-1) GLP-1 secretion. Probiotics are …

Targeting the PI3K/Akt signaling pathway in pancreatic β‐cells to enhance their survival and function: an emerging therapeutic strategy for type 1 diabetes

I Camaya, S Donnelly, B O'Brien - Journal of Diabetes, 2022 - Wiley Online Library
Abstract Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of the
insulin‐producing β‐cells within the pancreas. Islet transplantation represents one cure; …

The water extract of Radix scutellariae, its total flavonoids and baicalin inhibited CYP7A1 expression, improved bile acid, and glycolipid metabolism in T2DM mice

X Yan, Y Zhang, Y Peng, X Li - Journal of Ethnopharmacology, 2022 - Elsevier
Ethnopharmacological relevance Radix scutellariae (the root of Scutellaria baicalensis
Georgi), is a traditional Chinese medicine (TCM) used to treat type 2 diabetes mellitus …

Immunomodulatory potential of flavonoids for the treatment of autoimmune diseases and tumour

L Han, Q Fu, C Deng, L Luo, T Xiang… - … Journal of Immunology, 2022 - Wiley Online Library
The immune system plays an indispensable role in maintaining human health against the
invasion of foreign materials, microorgainisms and pathogens. The autoimmune diseases …

Baicalin and its aglycone: a novel approach for treatment of metabolic disorders

P Fang, M Yu, M Shi, P Bo, X Gu, Z Zhang - Pharmacological Reports, 2020 - Springer
Background The current strategies for prevention and treatment of insulin resistance and
type 2 diabetes are not fully effective and frequently accompanied by many negative effects …

The Herbal Medicine Scutellaria-Coptis Alleviates Intestinal Mucosal Barrier Damage in Diabetic Rats by Inhibiting Inflammation and Modulating the Gut Microbiota

B Zhang, R Yue, Y Chen, X Huang… - Evidence‐Based …, 2020 - Wiley Online Library
Recent studies have confirmed that increased intestinal permeability and gut‐origin
lipopolysaccharide (LPS) translocation are important causes of metabolic inflammation in …

Baicalin induced colon cancer cells apoptosis through miR-217/DKK1-mediated inhibition of Wnt signaling pathway

Y Jia, L Chen, S Guo, Y Li - Molecular biology reports, 2019 - Springer
To analyze the anti-tumor mechanism of Baicalin in human colon cancer. The MTT assay
and colony formation assay demonstrated that Baicalin treatment inhibits the proliferation of …

Scutellaria baicalensis georgi is a promising candidate for the treatment of autoimmune diseases

J Wang, S Chen, J Zhang, J Wu - Frontiers in pharmacology, 2022 - frontiersin.org
Autoimmune diseases a group of disorders elicited by unexpected outcome of lymphocytes
self-tolerance failure, and the common members of which include multiple sclerosis …