Eicosanoids via CYP450 and cardiovascular disease: Hints from genetic and nutrition studies
C Fava, S Bonafini - Prostaglandins & Other Lipid Mediators, 2018 - Elsevier
Metabolites of arachidonic acid via CYP450 such as epoxyeicosatrienoic acids (EETs) and
20-hydroxyeicosatetraenoic acid (20-HETE), have vasoactive and natriuretic properties and …
20-hydroxyeicosatetraenoic acid (20-HETE), have vasoactive and natriuretic properties and …
[HTML][HTML] Inflammation and endothelial function relevant genetic polymorphisms in carotid stenosis in southwestern China
L Liu, X Yi, H Luo, M Yu - Frontiers in Neurology, 2023 - frontiersin.org
Aim To evaluate the relationship between carotid stenosis with variants in genes referred to
inflammation and endothelial function. Methods There was a multi-center, cross sectional …
inflammation and endothelial function. Methods There was a multi-center, cross sectional …
Aspirin plus clopidogrel may reduce the risk of early neurologic deterioration in ischemic stroke patients carrying CYP2C19*2 reduced-function alleles
X Yi, Q Zhou, C Wang, J Lin, Z Chai - Journal of Neurology, 2018 - Springer
Objectives The mechanisms of early neurologic deterioration (END) and prevention
strategies for END are not completely understood. The aim of this study was to investigate …
strategies for END are not completely understood. The aim of this study was to investigate …
[HTML][HTML] CYP11B1 gene polymorphisms and susceptibility to ischemic stroke in a Chinese Han population
G Liu, Y Duan - Frontiers in Neuroscience, 2022 - frontiersin.org
Objectives Ischemic stroke (IS) is the major cause of death and disability. While previous
studies confirmed that CYP11B1 is closely associated with IS, the present study aimed to …
studies confirmed that CYP11B1 is closely associated with IS, the present study aimed to …
[HTML][HTML] Association between P2Y1 and P2Y12 polymorphisms and acute myocardial infarction and ADP-induced platelet aggregation
C Su, Z Zhang, J Chen, M Tian, C Wu… - BMC Cardiovascular …, 2023 - Springer
Background The objective of this study was to investigate the relationship between P2Y1
and P2Y12 genotypes and the risk of acute myocardial infarction (AMI) in the Quanzhou …
and P2Y12 genotypes and the risk of acute myocardial infarction (AMI) in the Quanzhou …
[HTML][HTML] The TXA2R rs1131882, P2Y1 rs1371097 and GPIIIa rs2317676 three-loci interactions may increase the risk of carotid stenosis in patients with ischemic …
X Yi, J Lin, Q Zhou, R Huang, Z Chai - BMC neurology, 2019 - Springer
Background The genetic risk factors for carotid stenosis are not fully understood. The aim of
this study is to investigate the relationship between variants in platelet activation-relevant …
this study is to investigate the relationship between variants in platelet activation-relevant …
Platelet membrane receptor P2Y12 H1/H2 polymorphism is highly associated with cerebral infarction: a case–control study
SJ Lu, XS Zhou, Q Zheng, HL Chen… - … Disease and Treatment, 2018 - Taylor & Francis
Objectives This study aimed to determine the relationship between the polymorphisms of the
H1/H2 gene of platelet membrane receptor P2Y12 and cerebral infarction (CI) in a Han …
H1/H2 gene of platelet membrane receptor P2Y12 and cerebral infarction (CI) in a Han …
[HTML][HTML] Variants in clopidogrel-relevant genes and early neurological deterioration in ischemic stroke patients receiving clopidogrel
X Yi, Q Zhou, Y Zhang, J Zhou, J Lin - BMC neurology, 2020 - Springer
Background Early neurological deterioration (END) is common in acute ischemic stroke (IS).
However, the underlying mechanisms for END are unclear. The aim of this study was to …
However, the underlying mechanisms for END are unclear. The aim of this study was to …
[HTML][HTML] Population-Specific Associations of Deleterious Rare Variants in Coding Region of P2RY1–P2RY12 Purinergic Receptor Genes in Large-Vessel Ischemic …
PK Janicki, C Eyileten, V Ruiz-Velasco… - International journal of …, 2017 - mdpi.com
The contribution of low-frequency and damaging genetic variants associated with platelet
function to ischemic stroke (IS) susceptibility remains unknown. We employed a deep re …
function to ischemic stroke (IS) susceptibility remains unknown. We employed a deep re …
[HTML][HTML] The secondary prevention of stroke according to cytochrome P450 2C19 genotype in patients with acute large-artery atherosclerosis stroke
X Yi, J Lin, J Zhou, Y Wang, R Huang, C Wang - Oncotarget, 2018 - ncbi.nlm.nih.gov
Purpose To investigated the effectiveness of antiplatelet agents for the secondary prevention
of stroke according to CYP2C19 genotype in patients with ischemic stroke (IS). Methods …
of stroke according to CYP2C19 genotype in patients with ischemic stroke (IS). Methods …