Nonhomologous DNA end-joining (NHEJ) is the predominant double-strand break (DSB)
repair pathway throughout the cell cycle and accounts for nearly all DSB repair outside of …

DNA double-stranded breaks (DSB) are among the most dangerous forms of DNA damage.
Unrepaired DSBs results in cells undergoing apoptosis or senescence whereas mis …

DNA double-strand breaks (DSBs) are a highly cytotoxic form of DNA damage and the
incorrect repair of DSBs is linked to carcinogenesis,. The conserved error-prone non …

DNA double-strand breaks pose a serious threat to genome stability. In vertebrates, these
breaks are predominantly repaired by nonhomologous end joining (NHEJ), which pairs DNA …

Nonhomologous end joining (NHEJ) refers to a set of genome maintenance pathways in
which two DNA double-strand break (DSB) ends are (re) joined by apposition, processing …

The occurrence of DNA double-strand breaks (DSBs) induced by ionizing radiation has
been extensively studied by biochemical or cell imaging techniques. Cell imaging …

The RNA-sensing pathway contributes to type I interferon (IFN) production induced by DNA
damaging agents. However, the potential involvement of RNA sensors in DNA repair is …

DNA non-homologous end-joining (NHEJ) is the major DNA double strand break (DSB)
repair pathway in mammalian cells. Defects in NHEJ proteins confer marked radiosensitivity …

One of the most central questions about the repair of a double-strand DNA break (DSB)
concerns how the two free DNA ends are brought together—a step called synapsis. Using …

DNA double-strand breaks pose a significant threat to cell survival and must be repaired. In
higher eukaryotes, such damage is repaired efficiently by non-homologous end joining …