Recent research on flavonoids and their biomedical applications

K Wen, X Fang, J Yang, Y Yao… - Current medicinal …, 2021 - ingentaconnect.com
Flavonoids, commonly found in various plants, are a class of polyphenolic compounds
having a basic structural unit of 2-phenylchromone. Flavonoid compounds have attracted …

Traditional Chinese medicine may be further explored as candidate drugs for pancreatic cancer: a review

Y Gao, S Chen, J Sun, S Su, D Yang… - Phytotherapy …, 2021 - Wiley Online Library
Pancreatic cancer is a disease with a high mortality rate. Although survival rates for different
types of cancers have improved in recent years, the five‐year survival rate of pancreatic …

[HTML][HTML] Orientin, a Bio-Flavonoid from Trigonella hamosa L., Regulates COX-2/PGE-2 in A549 Cell Lines via miR-26b and miR-146a

HE Khalil, HIM Ibrahim, EA Ahmed, PM Emeka… - Pharmaceuticals, 2022 - mdpi.com
Cancer is a severe health condition and considered one of the major healthcare issues and
is in need of innovative strategy for a cure. The current study aimed to investigate the …

[HTML][HTML] Isoorientin ameliorates APAP-induced hepatotoxicity via activation Nrf2 antioxidative pathway: The involvement of AMPK/Akt/GSK3β

X Fan, H Lv, L Wang, X Deng, X Ci - Frontiers in pharmacology, 2018 - frontiersin.org
Oxidative stress has been highlighted as therapeutic targets for acetaminophen (APAP)-
induced hepatotoxicity. Isoorientin (Iso), a well-known flavonoid-like compound, has been …

Antinociceptive effect of isoorientin against neuropathic pain induced by the chronic constriction injury of the sciatic nerve in mice

G Zhang, N Liu, C Zhu, L Ma, J Yang, J Du… - International …, 2019 - Elsevier
Neuropathic pain is a widespread and debilitating chronic pain and the treatment remains a
clinical challenge. Isoorientin (3′, 4′, 5, 7-tetrahydroxy-6-C-glucopyranosyl flavone) is a …

[HTML][HTML] UHPLC-MS Characterization and Biological Insights of Different Solvent Extracts of Two Achillea Species (A. aleppica and A. santolinoides) from Turkey

R Gevrenova, G Zengin, KI Sinan, E Yıldıztugay… - Antioxidants, 2021 - mdpi.com
In the current study, Achillea santolinoides and Achillea aleppica aeral parts and root were
extracted with ethyl acetate, methanol, and water. Detailed phytochemical profiles were …

[HTML][HTML] A mechanism of isoorientin-induced apoptosis and migration inhibition in gastric cancer AGS cells

T Zhang, YH Xiu, H Xue, YN Li, JL Cao, WS Hou, J Liu… - Pharmaceuticals, 2022 - mdpi.com
Isoorientin (ISO) is a flavonoid compound containing a luteolin structure, which can induce
autophagy in some tumor cells. This study investigated the impact of ISO in gastric cancer …

[HTML][HTML] Isoorientin induces the apoptosis and cell cycle arrest of A549 human lung cancer cells via the ROS‑regulated MAPK, STAT3 and NF‑κB signaling pathways

WT Xu, GN Shen, TZ Li, Y Zhang… - International …, 2020 - spandidos-publications.com
Isoorientin (ISO) is a naturally occurring C‑glycosyl flavone that has various pharmacological
properties, such as anti‑bacterial and anti‑inflammatory effects. However, its underlying …

Further isolation and identification of anti-diabetic principles from root bark of Myrianthus arboreus P. Beauv.: The ethyl acetate fraction contains bioactive phenolic …

PB Kasangana, HM Eid, A Nachar, T Stevanovic… - Journal of …, 2019 - Elsevier
Ethnopharmacological relevance We recently reported that ethanol extract of Myrianthus
arboreus P. Beauv. root bark demonstrated antidiabetic activity by modulating hepatocyte …

Isoorientin inhibits epithelial-to-mesenchymal properties and cancer stem-cell-like features in oral squamous cell carcinoma by blocking Wnt/β-catenin/STAT3 axis

SC Liu, CS Huang, CM Huang, MS Hsieh… - Toxicology and Applied …, 2021 - Elsevier
Oral squamous cell carcinoma (OSCC) is among the most prevalent cancers of the head
and neck. This study revealed that isoorientin attenuates OSCC cell stemness and epithelial …