Recent research on flavonoids and their biomedical applications
K Wen, X Fang, J Yang, Y Yao… - Current medicinal …, 2021 - ingentaconnect.com
Flavonoids, commonly found in various plants, are a class of polyphenolic compounds
having a basic structural unit of 2-phenylchromone. Flavonoid compounds have attracted …
having a basic structural unit of 2-phenylchromone. Flavonoid compounds have attracted …
Traditional Chinese medicine may be further explored as candidate drugs for pancreatic cancer: a review
Y Gao, S Chen, J Sun, S Su, D Yang… - Phytotherapy …, 2021 - Wiley Online Library
Pancreatic cancer is a disease with a high mortality rate. Although survival rates for different
types of cancers have improved in recent years, the five‐year survival rate of pancreatic …
types of cancers have improved in recent years, the five‐year survival rate of pancreatic …
[HTML][HTML] Orientin, a Bio-Flavonoid from Trigonella hamosa L., Regulates COX-2/PGE-2 in A549 Cell Lines via miR-26b and miR-146a
Cancer is a severe health condition and considered one of the major healthcare issues and
is in need of innovative strategy for a cure. The current study aimed to investigate the …
is in need of innovative strategy for a cure. The current study aimed to investigate the …
[HTML][HTML] Isoorientin ameliorates APAP-induced hepatotoxicity via activation Nrf2 antioxidative pathway: The involvement of AMPK/Akt/GSK3β
X Fan, H Lv, L Wang, X Deng, X Ci - Frontiers in pharmacology, 2018 - frontiersin.org
Oxidative stress has been highlighted as therapeutic targets for acetaminophen (APAP)-
induced hepatotoxicity. Isoorientin (Iso), a well-known flavonoid-like compound, has been …
induced hepatotoxicity. Isoorientin (Iso), a well-known flavonoid-like compound, has been …
Antinociceptive effect of isoorientin against neuropathic pain induced by the chronic constriction injury of the sciatic nerve in mice
G Zhang, N Liu, C Zhu, L Ma, J Yang, J Du… - International …, 2019 - Elsevier
Neuropathic pain is a widespread and debilitating chronic pain and the treatment remains a
clinical challenge. Isoorientin (3′, 4′, 5, 7-tetrahydroxy-6-C-glucopyranosyl flavone) is a …
clinical challenge. Isoorientin (3′, 4′, 5, 7-tetrahydroxy-6-C-glucopyranosyl flavone) is a …
[HTML][HTML] UHPLC-MS Characterization and Biological Insights of Different Solvent Extracts of Two Achillea Species (A. aleppica and A. santolinoides) from Turkey
In the current study, Achillea santolinoides and Achillea aleppica aeral parts and root were
extracted with ethyl acetate, methanol, and water. Detailed phytochemical profiles were …
extracted with ethyl acetate, methanol, and water. Detailed phytochemical profiles were …
[HTML][HTML] A mechanism of isoorientin-induced apoptosis and migration inhibition in gastric cancer AGS cells
T Zhang, YH Xiu, H Xue, YN Li, JL Cao, WS Hou, J Liu… - Pharmaceuticals, 2022 - mdpi.com
Isoorientin (ISO) is a flavonoid compound containing a luteolin structure, which can induce
autophagy in some tumor cells. This study investigated the impact of ISO in gastric cancer …
autophagy in some tumor cells. This study investigated the impact of ISO in gastric cancer …
[HTML][HTML] Isoorientin induces the apoptosis and cell cycle arrest of A549 human lung cancer cells via the ROS‑regulated MAPK, STAT3 and NF‑κB signaling pathways
WT Xu, GN Shen, TZ Li, Y Zhang… - International …, 2020 - spandidos-publications.com
Isoorientin (ISO) is a naturally occurring C‑glycosyl flavone that has various pharmacological
properties, such as anti‑bacterial and anti‑inflammatory effects. However, its underlying …
properties, such as anti‑bacterial and anti‑inflammatory effects. However, its underlying …
Further isolation and identification of anti-diabetic principles from root bark of Myrianthus arboreus P. Beauv.: The ethyl acetate fraction contains bioactive phenolic …
PB Kasangana, HM Eid, A Nachar, T Stevanovic… - Journal of …, 2019 - Elsevier
Ethnopharmacological relevance We recently reported that ethanol extract of Myrianthus
arboreus P. Beauv. root bark demonstrated antidiabetic activity by modulating hepatocyte …
arboreus P. Beauv. root bark demonstrated antidiabetic activity by modulating hepatocyte …
Isoorientin inhibits epithelial-to-mesenchymal properties and cancer stem-cell-like features in oral squamous cell carcinoma by blocking Wnt/β-catenin/STAT3 axis
SC Liu, CS Huang, CM Huang, MS Hsieh… - Toxicology and Applied …, 2021 - Elsevier
Oral squamous cell carcinoma (OSCC) is among the most prevalent cancers of the head
and neck. This study revealed that isoorientin attenuates OSCC cell stemness and epithelial …
and neck. This study revealed that isoorientin attenuates OSCC cell stemness and epithelial …