Further isolation and identification of anti-diabetic principles from root bark of Myrianthus arboreus P. Beauv.: The ethyl acetate fraction contains bioactive phenolic …

PB Kasangana, HM Eid, A Nachar, T Stevanovic… - Journal of …, 2019 - Elsevier
Ethnopharmacological relevance We recently reported that ethanol extract of Myrianthus
arboreus P. Beauv. root bark demonstrated antidiabetic activity by modulating hepatocyte …

Isoorientin inhibits epithelial-to-mesenchymal properties and cancer stem-cell-like features in oral squamous cell carcinoma by blocking Wnt/β-catenin/STAT3 axis

SC Liu, CS Huang, CM Huang, MS Hsieh… - Toxicology and Applied …, 2021 - Elsevier
Oral squamous cell carcinoma (OSCC) is among the most prevalent cancers of the head
and neck. This study revealed that isoorientin attenuates OSCC cell stemness and epithelial …

Isoorientin decreases cell migration via decreasing functional activity and molecular expression of proton-linked monocarboxylate transporters in human lung cancer …

HK Huang, SY Lee, SF Huang, YS Lin… - The American Journal …, 2020 - World Scientific
Aggressive tumor cells mainly rely on glycolysis, and further release vast amounts of lactate
and protons by monocarboxylate transporter (MCT), which causes a higher intracellular pH …

[HTML][HTML] Application of Quality by Design Approach to the Pharmaceutical Development of Anticancer Crude Extracts of Crocus sativus Perianth

O Mykhailenko, L Ivanauskas, I Bezruk… - Scientia …, 2022 - mdpi.com
The application of the Quality by Design (QbD) concept to extracts obtained from Crocus
sativus perianth with potential anticancer activity will ensure the safety, efficiency, and …

[HTML][HTML] PRKAA1 promotes proliferation and inhibits apoptosis of gastric cancer cells through activating JNK1 and Akt pathways

Y Zhang, X Zhou, L Cheng, X Wang, Q Zhang… - Oncology …, 2020 - ncbi.nlm.nih.gov
PRKAA1 (protein kinase AMP-activated catalytic subunit α 1) is a catalytic subunit of AMP-
activated protein kinase (AMPK), which plays a key role in regulating cellular energy …

In vitro assessment of the genotoxic and cytotoxic effects of clarified açai (Euterpe oleracea MART) extract in a gastric cancer cell line (AGP01 cells).

TS Santos, MO Bahia, AC Guimarães, CRT Souza… - Toxicology in Vitro, 2024 - Elsevier
Açaí (Euterpe oleracea MART) is a fruit of great importance for the Amazon region in
nutritional, cultural and socioeconomic terms. In recent years, açaí has been the subject of …

[HTML][HTML] Changes in Beneficial C-glycosylflavones and Policosanol Content in Wheat and Barley Sprouts Subjected to Differential LED Light Conditions

M Muthusamy, JH Kim, SH Kim, JY Kim, JW Heo… - Plants, 2020 - mdpi.com
The spectral quality and intensity of light, photoperiodism, and other environmental factors
have profound impacts on the metabolic composition of light-dependent higher plants …

Fundamental insights and molecular interactions in pancreatic cancer: Pathways to therapeutic approaches

M Gu, Y Liu, P Xin, W Guo, Z Zhao, X Yang, R Ma… - Cancer Letters, 2024 - Elsevier
The gastrointestinal tract can be affected by a number of diseases that pancreatic cancer
(PC) is a malignant manifestation of them. The prognosis of PC patients is unfavorable and …

Harnessing Plant Flavonoids to Fight Pancreatic Cancer

C Niu, J Zhang, PI Okolo - Current Nutrition Reports, 2024 - Springer
This review provides strong evidence that plant flavonoids have potential against pancreatic
carcinogenesis in experimental animals through various pharmacological mechanisms …

[HTML][HTML] Isoorientin triggers apoptosis of hepatoblastoma by inducing DNA double-strand breaks and suppressing homologous recombination repair

D Huang, Z Li, J Wu, N Zhang, D Zhou, X Ni… - Biomedicine & …, 2018 - Elsevier
Hepatoblastoma (HB) is the most common malignant liver tumor in children. DNA and DNA-
associated processes are one of the most important targets of chemotherapeutic agents …