Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1‐based vaccines to prevent it

AR Jensen, Y Adams, L Hviid - Immunological reviews, 2020 - Wiley Online Library
Malaria, a mosquito‐borne infectious disease caused by parasites of the genus Plasmodium
continues to be a major health problem worldwide. The unicellular Plasmodium‐parasites …

Antigenic Variation in Plasmodium falciparum

A Scherf, JJ Lopez-Rubio, L Riviere - Annu. Rev. Microbiol., 2008 - annualreviews.org
The persistence of the human malaria parasite Plasmodium falciparum during blood stage
proliferation in its host depends on the successive expression of variant molecules at the …

Plasmodium falciparum Erythrocyte Membrane Protein 1 Diversity in Seven Genomes – Divide and Conquer

TS Rask, DA Hansen, TG Theander… - PLoS computational …, 2010 - journals.plos.org
The var gene encoded hyper-variable Plasmodium falciparum erythrocyte membrane
protein 1 (PfEMP1) family mediates cytoadhesion of infected erythrocytes to human …

[HTML][HTML] Exported proteins required for virulence and rigidity of Plasmodium falciparum-infected human erythrocytes

AG Maier, M Rug, MT O'Neill, M Brown, S Chakravorty… - Cell, 2008 - cell.com
A major part of virulence for Plasmodium falciparum malaria infection, the most lethal
parasitic disease of humans, results from increased rigidity and adhesiveness of infected …

Plasmodium falciparum erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in children

T Lavstsen, L Turner, F Saguti… - Proceedings of the …, 2012 - National Acad Sciences
The clinical outcome of Plasmodium falciparum infections ranges from asymptomatic
parasitemia to severe malaria syndromes associated with high mortality. The virulence of P …

Surface antigens of Plasmodium falciparum-infected erythrocytes as immune targets and malaria vaccine candidates

JA Chan, FJI Fowkes, JG Beeson - Cellular and Molecular Life Sciences, 2014 - Springer
Understanding the targets and mechanisms of human immunity to malaria caused by
Plasmodium falciparum is crucial for advancing effective vaccines and developing tools for …

Malaria in pregnancy: from placental infection to its abnormal development and damage

CLL Chua, SKM Khoo, JLE Ong… - Frontiers in …, 2021 - frontiersin.org
Malaria remains a global health burden with Plasmodium falciparum accounting for the
highest mortality and morbidity. Malaria in pregnancy can lead to the development of …

Afucosylated Plasmodium falciparum-specific IgG is induced by infection but not by subunit vaccination

MD Larsen, M Lopez-Perez, EK Dickson… - Nature …, 2021 - nature.com
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family members mediate
receptor-and tissue-specific sequestration of infected erythrocytes (IEs) in malaria. Antibody …

[HTML][HTML] Malaria in pregnancy: linking immunity and pathogenesis to prevention

SJ Rogerson, V Mwapasa… - Defining and Defeating …, 2007 - ncbi.nlm.nih.gov
Pregnant women are susceptible to malaria during pregnancy. Plasmodium falciparum,
which sequesters in the placenta, causes the greatest disease, contributing significantly to …

Antigenic Variation in Plasmodium falciparum: Gene Organization and Regulation of the var Multigene Family

SA Kyes, SM Kraemer, JD Smith - Eukaryotic cell, 2007 - Am Soc Microbiol
Plasmodium falciparum imposes an enormous burden upon the developing world, with 300
to 500 million cases and 1 to 2 million deaths per year (94). Despite extensive research …