Inborn errors of human IL-17 immunity underlie chronic mucocutaneous candidiasis
A Puel, S Cypowyj, L Maródi, L Abel… - Current opinion in …, 2012 - journals.lww.com
Inborn errors of human IL-17 immunity underlie chronic mucoc... : Current Opinion in Allergy and
Clinical Immunology Inborn errors of human IL-17 immunity underlie chronic mucocutaneous …
Clinical Immunology Inborn errors of human IL-17 immunity underlie chronic mucocutaneous …
Primary immunodeficiencies underlying fungal infections
F Lanternier, S Cypowyj, C Picard… - Current opinion in …, 2013 - journals.lww.com
CMC, invasive candidiasis, invasive aspergillosis, deep dermatophytosis, pneumocystosis,
and endemic mycoses can all be caused by PIDs. Each type of infection is highly suggestive …
and endemic mycoses can all be caused by PIDs. Each type of infection is highly suggestive …
Identification of a T follicular helper cell subset that drives anaphylactic IgE
INTRODUCTION Cross-linking of high-affinity, allergen-specific immunoglobulin E (IgE) on
mast cells results in anaphylaxis, a potentially life-threatening allergic reaction. The cellular …
mast cells results in anaphylaxis, a potentially life-threatening allergic reaction. The cellular …
DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity
DOCK8 mutations result in an inherited combined immunodeficiency characterized by
increased susceptibility to skin and other infections. We show that when DOCK8-deficient T …
increased susceptibility to skin and other infections. We show that when DOCK8-deficient T …
The multiple faces of leukocyte interstitial migration
T Lämmermann, RN Germain - Seminars in immunopathology, 2014 - Springer
Spatiotemporal control of leukocyte dynamics within tissues is critical for successful innate
and adaptive immune responses. Homeostatic trafficking and coordinated infiltration into …
and adaptive immune responses. Homeostatic trafficking and coordinated infiltration into …
Immunity to infection in IL‐17‐deficient mice and humans
S Cypowyj, C Picard, L Maródi… - European journal of …, 2012 - Wiley Online Library
Mice with defective IL‐17 immunity display a broad vulnerability to various infectious agents
at diverse mucocutaneous surfaces. In humans, the study of patients with various primary …
at diverse mucocutaneous surfaces. In humans, the study of patients with various primary …
Actin cytoskeletal defects in immunodeficiency
The importance of the cytoskeleton in mounting a successful immune response is evident
from the wide range of defects that occur in actin‐related primary immunodeficiencies (PID …
from the wide range of defects that occur in actin‐related primary immunodeficiencies (PID …
Atopic dermatitis, STAT 3‐and DOCK 8‐hyper‐IgE syndromes differ in IgE‐based sensitization pattern
AC Boos, B Hagl, A Schlesinger, BE Halm… - Allergy, 2014 - Wiley Online Library
Abstract Background Increased serum IgE levels are characteristic but not specific for
allergic diseases. Particularly, severe atopic dermatitis (AD) overlaps with hyper‐IgE …
allergic diseases. Particularly, severe atopic dermatitis (AD) overlaps with hyper‐IgE …
[HTML][HTML] Mechanism-based strategies for the management of autoimmunity and immune dysregulation in primary immunodeficiencies
JE Walter, JR Farmer, Z Foldvari, TR Torgerson… - The Journal of Allergy …, 2016 - Elsevier
A broad spectrum of autoimmunity is now well described in patients with primary
immunodeficiencies (PIDs). Management of autoimmune disease in the background of PID …
immunodeficiencies (PIDs). Management of autoimmune disease in the background of PID …
Dedicator of cytokinesis 8–deficient CD4+ T cells are biased to a TH2 effector fate at the expense of TH1 and TH17 cells
Background Dedicator of cytokinesis 8 (DOCK8) deficiency is a combined immunodeficiency
caused by autosomal recessive loss-of-function mutations in DOCK8. This disorder is …
caused by autosomal recessive loss-of-function mutations in DOCK8. This disorder is …