Autophagy in kidney homeostasis and disease
C Tang, MJ Livingston, Z Liu, Z Dong - Nature Reviews Nephrology, 2020 - nature.com
Autophagy is a conserved lysosomal pathway for the degradation of cytoplasmic
components. Basal autophagy in kidney cells is essential for the maintenance of kidney …
components. Basal autophagy in kidney cells is essential for the maintenance of kidney …
Maintaining proteostasis under mechanical stress
J Höhfeld, T Benzing, W Bloch, DO Fürst, S Gehlert… - EMBO …, 2021 - embopress.org
Cell survival, tissue integrity and organismal health depend on the ability to maintain
functional protein networks even under conditions that threaten protein integrity. Protection …
functional protein networks even under conditions that threaten protein integrity. Protection …
3D organoid-derived human glomeruli for personalised podocyte disease modelling and drug screening
The podocytes within the glomeruli of the kidney maintain the filtration barrier by forming
interdigitating foot processes with intervening slit diaphragms, disruption in which results in …
interdigitating foot processes with intervening slit diaphragms, disruption in which results in …
The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis
J Xie, L Liu, N Mladkova, Y Li, H Ren, W Wang… - Nature …, 2020 - nature.com
Membranous Nephropathy (MN) is a rare autoimmune cause of kidney failure. Here we
report a genome-wide association study (GWAS) for primary MN in 3,782 cases and 9,038 …
report a genome-wide association study (GWAS) for primary MN in 3,782 cases and 9,038 …
A molecular mechanism explaining albuminuria in kidney disease
L Butt, D Unnersjö-Jess, M Höhne, A Edwards… - Nature …, 2020 - nature.com
Mammalian kidneys constantly filter large amounts of liquid, with almost complete retention
of albumin and other macromolecules in the plasma. Breakdown of the three-layered renal …
of albumin and other macromolecules in the plasma. Breakdown of the three-layered renal …
[HTML][HTML] Neural cell adhesion molecule 1 is a novel autoantigen in membranous lupus nephritis
TN Caza, SI Hassen, M Kuperman, SG Sharma… - Kidney international, 2021 - Elsevier
Membranous lupus nephritis is a frequent cause of nephrotic syndrome in patients with
systemic lupus erythematosus. It has been shown in phospholipase A2 receptor positive …
systemic lupus erythematosus. It has been shown in phospholipase A2 receptor positive …
Discovery of seven novel putative antigens in membranous nephropathy and membranous lupus nephritis identified by mass spectrometry
TN Caza, AJ Storey, SI Hassen, C Herzog… - Kidney international, 2023 - Elsevier
Multiple autoantigens have been identified in membranous nephropathy (MN) by tissue-
based proteomics. However, antigenic targets of disease are unknown for over 10% of …
based proteomics. However, antigenic targets of disease are unknown for over 10% of …
Serine protease HTRA1 as a novel target antigen in primary membranous nephropathy
LF Al-Rabadi, T Caza, C Trivin-Avillach… - Journal of the …, 2021 - journals.lww.com
Background Identification of target antigens PLA2R, THSD7A, NELL1, or Semaphorin-3B
can explain the majority of cases of primary membranous nephropathy (MN). However …
can explain the majority of cases of primary membranous nephropathy (MN). However …
Accumulation of α-synuclein mediates podocyte injury in Fabry nephropathy
F Braun, A Abed, D Sellung, M Rogg… - The Journal of …, 2023 - Am Soc Clin Investig
Current therapies for Fabry disease are based on reversing intracellular accumulation of
globotriaosylceramide (Gb3) by enzyme replacement therapy (ERT) or chaperone-mediated …
globotriaosylceramide (Gb3) by enzyme replacement therapy (ERT) or chaperone-mediated …
Expansion-enhanced super-resolution radial fluctuations enable nanoscale molecular profiling of pathology specimens
Expansion microscopy physically enlarges biological specimens to achieve nanoscale
resolution using diffraction-limited microscopy systems. However, optimal performance is …
resolution using diffraction-limited microscopy systems. However, optimal performance is …