Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection

J Egea, I Buendia, E Parada, E Navarro, R Leon… - Biochemical …, 2015 - Elsevier
Nicotinic acetylcholine receptors (nAChRs) are widely distributed throughout the central
nervous system, being expressed in neurons and non-neuronal cells, where they participate …

The role of astrocytic α7 nicotinic acetylcholine receptors in Alzheimer disease

IC Fontana, A Kumar, A Nordberg - Nature Reviews Neurology, 2023 - nature.com
The ongoing search for therapeutic interventions in Alzheimer disease (AD) has highlighted
the complexity of this condition and the need for additional biomarkers, beyond amyloid-β …

[HTML][HTML] How reliable are G-protein-coupled receptor antibodies?

MC Michel, T Wieland, G Tsujimoto - Naunyn-Schmiedeberg's archives of …, 2009 - Springer
A cluster of manuscripts in this issue of the Journal highlights a lack of selectivity of 49
antibodies against 19 subtypes of α 1-and β-adrenoceptors, muscarinic, dopamine and …

Therapeutic targeting of α7 nicotinic acetylcholine receptors

RL Papke, NA Horenstein - Pharmacological Reviews, 2021 - ASPET
The α 7-type nicotinic acetylcholine receptor is one of the most unique and interesting of all
the members of the cys-loop superfamily of ligand-gated ion channels. Since it was first …

Therapeutic potential of α7 nicotinic acetylcholine receptors

D Bertrand, CHL Lee, D Flood, F Marger… - Pharmacological …, 2015 - ASPET
Progress in the fields of neuroscience and molecular biology has identified the forebrain
cholinergic system as being important in many higher order brain functions. Further analysis …

Precise localization of α7 nicotinic acetylcholine receptors on glutamatergic axon terminals in the rat ventral tegmental area

IW Jones, S Wonnacott - Journal of Neuroscience, 2004 - Soc Neuroscience
α7 neuronal nicotinic acetylcholine receptors (nAChRs) constitute one of the predominant
nAChR subtypes in the mammalian brain. Within the ventral tegmental area (VTA), nicotine …

[HTML][HTML] The epithelial cholinergic system of the airways

W Kummer, KS Lips, U Pfeil - Histochemistry and cell biology, 2008 - Springer
Acetylcholine (ACh), a classical transmitter of parasympathetic nerve fibres in the airways, is
also synthesized by a large number of non-neuronal cells, including airway surface …

[HTML][HTML] Signaling of nicotinic acetylcholine receptors in mononuclear phagocytes

K Richter, V Grau - Pharmacological Research, 2023 - Elsevier
Nicotinic acetylcholine receptors are not only expressed by the nervous system and at the
neuro-muscular junction but also by mononuclear phagocytes, which belong to the innate …

Evaluating the suitability of nicotinic acetylcholine receptor antibodies for standard immunodetection procedures

N Moser, N Mechawar, I Jones… - Journal of …, 2007 - Wiley Online Library
Nicotinic acetylcholine receptors play important roles in numerous cognitive processes as
well as in several debilitating central nervous system (CNS) disorders. In order to fully …

[HTML][HTML] Neuro-anatomical evidence indicating indirect modulation of macrophages by vagal efferents in the intestine but not in the spleen

C Cailotto, PJ Gomez-Pinilla, LM Costes… - PloS one, 2014 - journals.plos.org
Background Electrical stimulation of the vagus nerve suppresses intestinal inflammation and
normalizes gut motility in a mouse model of postoperative ileus. The exact anatomical …