Somatic cell nuclear transfer (SCNT) has broad applications but is limited by low cloning
efficiency. In this review, we mainly focus on SCNT-mediated epigenetic reprogramming in …

Germline editing, the process by which the genome of an individual is edited in such a way
that the change is heritable, has been applied to a wide variety of animals [DA Sorrell, AF …

In the pig, the efficiency of in vitro embryo production and somatic cell nuclear transfer
(SCNT) procedures remains limited. It has been suggested that prematuration treatments …

A functional canonical WNT signaling pathway exists in preimplantation embryos and
inhibits embryonic development. Recent studies suggest that this pathway is over-expressed …

Spermatogonial stem cells (SSCs) are the foundation of spermatogenesis and essential to
maintain the continuous production of spermatozoa after the onset of puberty in the male …

Simple Summary Cloning is the most promising technique for passing the excellent
phenotypes of the best individuals in the population. Here we studied the effects of cloning …

The application of cloning technology on a large scale is limited by very low offspring rate
primarily due to aberrant or incomplete epigenetic reprogramming. Trichostatin A (TSA), a …

Low development of somatic cell nuclear transfer embryos could be due to the incomplete
DNA methylation reprogramming, and Dnmt1s existing in donor cells may be one cause of …

Genetic modification of livestock has a longstanding and successful history, starting with
domestication several thousand years ago. Modern animal breeding strategies …

Recent advances in embryology and related research offer considerable possibilities to
accelerate genetic improvement in cattle breeding. Such progress includes optimization and …