For around three decades, the fluoroquinolone (FQ) antibiotic ciprofloxacin has been used
to treat a range of diseases, including chronic otorrhea, endocarditis, lower respiratory tract …

Bacterial antibiotic resistance, especially the emergence of multidrug-resistant (MDR)
strains, urgently requires the development of effective treatment strategies. It is always of …

Background: Methicillin-resistant Staphylococcus aureus (MRSA) has now become a major
nosocomial pathogen bacteria and resistant to many antibiotics. Therefore, Development of …

Streptococcus agalactiae (GBS) is an important pathogenic bacteria that infected both
aquatic animals and human beings, causing huge economic loss. The increasing cases of …

Introduction The overuse of antibiotics has made public health and safety face a serious
cisis. It is urgent to develop new clinical treatment methods to combat drug resistant bacteria …

Antibiotic resistance is an increasing concern for human and animal health worldwide.
Recently, the concept of reverting bacterial resistance by changing the metabolic state of …

As multidrug-resistant pathogens emerge and spread rapidly, novel antibiotics urgently
need to be discovered. With a dwindling antibiotic pipeline, antibiotic adjuvants might be …

Nucleotide metabolism plays a central role in bacterial physiology, producing the nucleic
acids necessary for DNA replication and RNA transcription. Recent studies demonstrate that …

Serratia marcescens is now becoming a propensity for its highly antimicrobial-resistant
clinical infections. Currently, it provides a novel strategy to prevent and control microbial …

Introduction The consumption of probiotics may influence children's gut microbiome and
metabolome, which may reflect shifts in gut microbial diversity composition and metabolism …