Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

Capsaicin in chili peppers bestows the sensation of spiciness. Since the discovery of its
receptor, transient receptor potential vanilloid 1 (TRPV1) ion channel, how capsaicin …

Transient receptor potential (TRP) channels are cellular sensors for a wide spectrum of
physical and chemical stimuli. They are involved in the formation of sight, hearing, touch …

Hereditary channelopathies, that is, mutations in channel genes that alter channel function
and are causal for the pathogenesis of the disease, have been described for several …

The Transient Receptor Potential Vanilloid 4 channel, TRPV4, is a Ca2+ and Mg2+
permeable non-selective cation channel involved in many different cellular functions. It is …

Precise regulation of calcium homeostasis is essential for many physiological functions. The
Ca2+-selective transient receptor potential (TRP) channels TRPV5 and TRPV6 play vital …

Abstract Charcot-Marie-Tooth disease type 2C (CMT2C) is an autosomal dominant
neuropathy characterized by limb, diaphragm and laryngeal muscle weakness. Two …

When we edited in 2007 the first issue on transient receptor potential channel in the
Handbook of Experimental Pharmacology, we were all very excited by the progress in this …

The exceptionally high temperature sensitivity of certain transient receptor potential (TRP)
family ion channels is the molecular basis of hot and cold sensation in sensory neurons. The …

Spinal muscular atrophies (SMA, also known as hereditary motor neuropathies) and
hereditary motor and sensory neuropathies (HMSN) are clinically and genetically …