Metabolic reprogramming occurs in tumors to foster cancer cell proliferation, survival and
metastasis, but as well at a systemic level affecting the whole organism, eventually leading …

Cancer cachexia syndrome is a major cause of morbidity and mortality in cancer patients in
the advanced stage. It is a devastating disorder characterized by nutritional impairment …

Cancer cachexia is characterized by a significant reduction in body weight resulting
predominantly from loss of adipose tissue and skeletal muscle. Cachexia causes reduced …

Cachexia is the loss of lean body mass (LBM) that affects a large proportion of dogs and cats
with congestive heart failure (CHF), chronic kidney disease (CKD), cancer, and a variety of …

Over the last two decades, new insights into the etiology of skeletal muscle wasting/atrophy
under diverse clinical settings including denervation, AIDS, cancer, diabetes, and chronic …

Impaired kidney function and chronic kidney disease (CKD) leading to kidney failure and
end-stage renal disease (ESRD) is a serious medical condition associated with increased …

The loss of appetite that typically accompanies infection or mere exposure to parasites is
traditionally considered a negative byproduct of infection, benefitting neither the host nor the …

The mammalian circadian system regulates many physiological functions including
inflammatory responses. Appropriately timed light information is essential for maintaining …

The hypothalamic arcuate nucleus contains two anatomically and functionally distinct
populations of neurons—the agouti-related peptide (AgRP)-and pro-opiomelanocortin …

Anorexia and metabolic alterations are the main components of the cachectic syndrome.
Glucose intolerance, fat depletion, muscle protein catabolism and other alterations are …